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In my experience, it's not unusual, though not common, for people (usually parties) to refuse to testify in a civil case based on the 5th amendment. The other side can ask the court to draw an adverse inference from this. I know an aggressive litigator who sometimes has his clients do this. He says "you won't win your case with your adverse inference."

That may be true, but the 5th amendment seems like a risky civil strategy to me. Usually the other side won't be entirely dependent on your testimony to prove their case. There can be other evidence out there that you might want to explain with your testimony, or you may otherwise wish to make your case with testimony.

It's worth knowing that in a civil case the 5th amendment is much less powerful and has risks as well as benefits.

If there is other evidence to meet balance of probabilities, it's irrelevant whether you say something or not. Saying something is more likely to cause you trouble and open up avenues to hang you out to dry.

Of course, were that to be the case, any sensible lawyer would tell you to make a settlement pre-trial. That way the 5th is never an issue, nor is any testimony which would otherwise go on official record and be searchable for all time.

Your statement "other evidence to meet balance of probabilities" is concise but so abstract it's useless. Like most legal questions, there is no abstract way to reason about this. The answer is always "it depends on the context."
Has there been any research on the effectiveness of jury instructions? It seems that telling people to discard evidence (in a Bayesian sense) is simply an invalid idea. People have internal biases and you can't make them compensate by telling them to.
Not to mention, have you ever listened to jury instructions? They are so incredibly boring and convoluted that most peoples eyes just glaze over. It's not the juries don't follow the instructions, it's that many of them don't listen and don't understand the instructions in the first place.
Since Americans typically commit three felonies a day, can you always take the Fifth? You were possibly committing a crime and don't even know it.