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I don't? I even use group policy to disable Windows Defender. Then I just apply Windows updates as they come out.

Sorry, but it's hard to give meaningful advice without more details. What threats are you hoping to protect against? Is it for your own machine, or someone else's? How experienced and cautious is the user?

Bitdefender, though I'm starting to look at Malwarebytes.
I do like ESET but I do have a machine where I don't use an antivirus and have chosen to only run a Firewall in interactive mode (block/allow stuff as it tries to communicate with the internet), Windows 10 Firewall Control Free works well (it also works on Windows7/8, it's just called that).
My current security setup on Windows 10 is;

1) Comodo Firewall

2) Comodo Host Intrusion Prevention System (HIPS)

3) Comodo Sandbox

4) Microsoft Enhanced Mitigation Experience Toolkit (EMET)

5) Peerblock with an iBlockList subscription

I've also got MalwareBytes and ComboFix for on-demand scans once in a while.

I have Windows Firewall and Defender both disabled.

Windows Defender + adblocker + hosts file
Kaspersky because what's better than a Russian anti-virus to protect the American OS of a French geek ;-)

Sophos at work which I find kind of meh.

Avira if I need something free.

Avira is also one of the best performing scanners.
Webroot SecureAnywhere Endpoint. Really light on the memory and works well for me.