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Congrats on the move, Paul, and good luck in San Francisco!
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If you can put up with it, I'd recommend doing a short term lease while you get a feel for the city. There are advantages and disadvantages to different parts, and I don't think you'll have a good idea of what's right for you until you've been immersed/found employment, etc. Bring a bicycle and plan on spending some time getting acquainted with the city.

Something like Lower Haight, SOMA, or Duboce Triangle area is centrally located and would be a good starting point to explore.

I will second Duboce Triangle, I live in this area and find that it has excellent bus and train routes to just about everywhere in the city.
Be prepared that SF != Silicon Valley. Different culture, different companies, 1 hour+ commute or so each way.
To be honest I used both terms in the title for SEO purposes.