Ask HN: What are the obstacles to bootstrap Lisp machine on Cello's bio Verilog?

In "Nexus" by Ramez Naam, the central protagonist builds an operating system that runs on nano tech and interfaces with his brain. I know we're obviously a ways away from that spectacular hacker fantasy, but I've noticed some interesting projects the last few years that have left me wondering if they might constitute a path towards building a biologically based Lisp system.

First off, Cello ( http://cidarlab.org/cello/ ) is a way to build genetic circuits with Verilog.

Secondly, there is a lot of prior art about building Lisp Machine's on FPGA's and with Verilog and it's cousins:

https://github.com/lisper/cpus-caddr

http://www.frank-buss.de/lispcpu/

http://www.aviduratas.de/lisp/lispmfpga/

https://github.com/jbush001/LispMicrocontroller

It's seems to me that Lisp Machine's died out for a variety of market and hardware reasons, but if it's possible to bootstrap them in biological systems this could be Lisp's last laugh!

I don't have the chops right now to take this idea further than speculation, but I know that y'all are definitely the folks to ask for more direction. Is there a clear path here? How would you go about building a "shell in a cell"?