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This is a shameless plug and only marginally related, but I've done a decent amount of self research in buying dumb supplements and hoping they work (especially with nootropics).

I created https://betterself.io/, open-sourced at https://github.com/jeffshek/betterself, but the gist of it was -- how do I find out what supplements are really just the placebo effect versus having a strong correlation (positive or negative) on my productivity/sleep?

Aggregating data across either 7/14 periods removed a lot of noise and let me improve on the supplements I was already buying (and let me dump out a lot).