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Is there a better version of this idea written somewhere I can share? Something with not so much sarcasm and more reason.
I'll trade you an anecdote, for whatever it's worth: One of my earlier memories was learning in school that your daily intake should be mostly grain. But recently, after cutting grain out of my diet completely, I went from 240lbs to 210 with zero exercise.

It's weird to realize that pretty much no one knows what's up with nutrition. It's the opposite of data-driven.

The food pyramid in the US wasn’t devised by nutritionists. It was designed by the farm lobby. It was published by the Department of Agriculture.
It's absolutely data-driven. By food and farm lobbies that do not have your health as their priority.
That doesn't surprise me in the least. Grain is very caloric. Cutting grain out of your diet almost certainly means you're eating fewer calories per day.

That said, current nutritional recommendation is 45–65% of your caloric intake should be complex carbohydrates. Now that doesn't necessarily mean grain, but grain is an easy source.

Why would cutting grains somehow not trigger hunger until the calories have been replaced?
In general, in the modern world (or at least, in the US) we tend to overeat. We're not just eating to satisfy hunger, we're eating for many reasons. Furthermore, it takes your body some time to react to putting food in your stomach (this is why you eat more if you eat fast than if you take your time).

Basically what I'm saying is, eating fewer calories doesn't necessarily mean you're hungry, because putting food into your mouth isn't just a reaction to being hungry, and because we tend to eat more than is necessary to satisfy hunger anyway.

I'm not contesting the other points you bring up, but hunger is the major challenge in calorie-restricted diets.
As someone who's currently on a calorie-restricted diet, yes, hunger is a big problem.

However, eating fewer calories by cutting out grains is not the same thing as being on a calorie-restricted diet.

Isn't it automatically a calorie-restricted diet if you are eating fewer calories than you normally would?

FWIW I also have cut out grains but my weight is very stable, so it seems fair to assume I now just eat more of other things.

Define "normally would", because people's calorie intake varies from day to day. Also, previously I claimed that people have a tendency to eat more than they should, so scaling back on that isn't calorie restriction, it's just the absence of extra calories.

More generally, it's just a bit pedantic to say that eating fewer calories than you would otherwise should be called a "calorie-restricted diet". The first reason is because the phrase "calorie-restricted diet" implies a significant restriction instead (for example, I'm only 1200 calories per day right now; that's a significant restriction compared to what I would be eating if I wanted to maintain my current weight). The second reason is because "calorie-restricted diet" implies a diet focused around tracking calories. Cutting out grains isn't a diet focused on calorie intake (heck, it's not tracking calories at all), it's just a diet that has the side effect of likely reducing calorie intake.

Hunger is not perfectly tied to caloric intake- part of the problem with, say, sugary sodas is that they won't fill you up no matter how much you drink.
Switch to a very high fiber diet, like lots of leafy greens. They slow digestion and can help lower your glycemic index. Most grains are simple carbohydrates, which mean you'll have a rapid increase in your blood sugar, this causes an insulin response. High insulin causes your body to convert said sugar to fat. Over time and weight gain your body can become resistant to the insulin, so it stays in your blood stream longer. Ask any diabetic that has taken too much insulin, that insulin hanging around is a bad thing. You will feel extremely hungry, causing an overeating response, which again raises ones blood sugar. Another insulin shot is needed, and if not dosed correctly puts too much insulin the blood stream. You can see who this leads to a very destructive cycle.
> Grain is very caloric.

That's kind of a misleading sentence. Fat is about 9 kcal per g. Carbohydrates and proteins are about 4 kcal per g (it's slightly more complicated than that because proteins have slightly higher caloric content, but take energy to absorb, while larger carbohydrates are can not be absorbed at all, but let's just take these as rough values).

Grain isn't very "caloric" at all compared to, say, butter. 10g of white flour is 36 kcal, while 10g of butter is 72 kcal. Compared to lettuce it's quite "caloric". 10g of lettuce gives you only 2 kcal. But that's because lettuce is all water.

Although I really like eating grains, I'm also a pretty big fan of vegetables. If you imagine that a meal is about 600 kcal (give or take), I think it's instructive to assemble a variety of food and see what quantity of food that is. 3/4 of a stick of butter; or half a loaf of bread (assuming a 1 lb loaf); or 6 large heads of iceberg lettuce.

You can see pretty easily that if you want to eat more food, while maintaining the same caloric intake, then vegetables are the way to go -- because they have a lot of water. But you can also have soups, etc to get the same effect. Even grains work well: a bowl of porridge made with 250 ml of semi skimmed milk is only 254 kcal according to google -- but that tablespoon of brown sugar is going to bump it up to over 300 kcal.

So that's really the thing: if you remove water from stuff (flour, sugar, oil, butter) it's pretty calorie dense -- especially oils and fats. Eating things that are essentially dried out conglomerations of these things (potato chips, cookies, muffins, cheese, granola, etc, etc) means that you can only eat a ridiculously small amount of food if you are trying to hit a calorie target. Virtually all of our "convenience foods" fall into that category -- even sandwiches are often bread, meat, mayonnaise and a token slice of greenery. The secret is to cook so as to maintain flavour while keeping the water content up (or to enjoy eating more intense foods, with much smaller portions).

In the past, "nutrition" meant "getting enough calories", as in the opposite of malnutrition. Grains are plentiful, cheap calories and so they are "nutritious".

Of course if you cut them out of your diet and still eat the same amounts of everything else you will lose weight, that's just thermodynamics!

Well technically you could just gain weight more slowly.
Exactly. In the past, calorie intake was probably the most important aspect of food nutrition. We live in good times.
> It's weird to realize that pretty much no one knows what's up with nutrition. It's the opposite of data-driven.

Did you track your calories? Dropping grains almost certainly means you cut your calories and thus lost weight. Exercise doesn't burn as many calories as people think. The adage 'abs are made in the kitchen, not the gym' rings true.

Eh, Abs are made in the gym. Fat is made in the kitchen. You can be both skinny and not ripped at the same time.
> You can be both skinny and not ripped at the same time.

Of course, the point is there is almost no amount of exercise (8 hours/day in the pool like Phelps maybe) that can make up for a bad diet when it comes to abs. Abs are almost strictly a function of body fat percentage.

Yeah, it is just difficult to eat enough calories when you eliminate grains. That doesn't really mean it's better or worse nutrition.
My general philosophy about nutrition is simply to listen to my own body. As in: how does this meal that I just ate or drink that I just drank make me feel? I've noticed with certain foods, I have strange feelings after eating them, so I'll tend to stay away from eating them regularly or even at all.

I'm not sure if there's any merit to this way of considering my diet, but it feels like the most sensible approach towards deciding what I should or shouldn't eat.

Smoking cigarettes makes me feel amazing, so I'm not convinced about your approach.
When you smoke one, yes. How long until you feel worse?
I'm sure they do in the immediate short term, but don't you cough up mucus[1], have a reduced sense of smell[2], yellowed teeth[3] and a smaller penis[4]?

That doesn't sound too amazing to me.

[1] https://www.medicalnewstoday.com/articles/318931.php

[2] https://www.webmd.com/smoking-cessation/features/is-smoking-...

[3] https://www.dentalhealth.org/tell-me-about/topic/sundry/smok...

[4] http://time.com/4408977/erectile-dysfunction-quit-smoking/

Been smoking for about 8 years

No to mucus

Maybe to reduced smell (doesn't seem significantly worse in practice than anyone else)

Maybe to teeth, but I also drink a lot of coffee, and its not very substantially yellow

Erectile dysfunction != smaller penis, and afaik, none of the (actually) described effects in the article apply to me, at least enough to have noticed.

Also that last article is the only one I checked, and is citing studies composed of 40 (2016 study), and 65 (2012), participants. The first is about fertility, and nothing to do with ED or penis size.

And the second study compares 20 successful quitters against 40 not, with apparently 13 people starting with ED, (distribution after the study left unspecified), and only claims that the quitters had larger erections than the smokers. (Not comparing before/after quitting on the same individual; just which group had the larger dicks at the end (their state at the beginning left unspecified).

And the ED part is just bad reporting (despite being the article's title), intentionally referring to results that are "statistically insignificant". (13 people with ED; quitters/non-quitter count unspecified; both groups saw similar improvement during the study).

I'm assuming you didn't read the studies themselves, so I won't bother

I'm also going to assume the rest of your articles are of similar quality

In which case, you should probably improve your sources before making claims

The 4th reference I provided attributed the possibility of both weaker erections and a smaller circumference penis among active smokers. Did you read it?

> Results underscore the possibility that cigarette use may deleteriously affect erectile function peripherally, in part, by disrupting cardiac autonomic function.

It's not the gold standard of proof, but it seems not too far fetched.

Most of the problems with smoking are actually caused by small circulation blood flow issues. And then to worse oxygenation. This is a common cause of ED but finding enough evidence will be tricky as it is not reported well. So don't get too hung up (sic) on that point.

Some people are more susceptible than others, and even then the telltale (as in other than "worse on ergometer") medical issues tend to start after years (sometimes many) of smoking. Based on stats it is about 20 years of delay in specific cancers. Then they are hard to reverse.

Sample of 1 is not compelling.

>Did you read it?

Yes, the problem is that I read it.

It indeed attributed the possibility, but at least from the article alone, the supporting evidence is incredibly weak. at the end of the study, a group of 20 people who quit had larger erections than a group of 40 who didn't.

Were they larger before the study too? Unstated.

Were they significantly larger? By how much? Unstated.

Were all of them larger, or did a few just skew the average? Unstated.

Was the quitting group larger than before they quit? Unstated.

All we have is that, in the end, the quitters had the larger, presumably average, erections. On a sample size of 20, and 40.

And of course, knowing that the article's headline is bullshit (claimed on results the writer himself acknowledges as statistically insignificant), it's probably likely that any other interpretation the author so freely takes is also bullshit.

That article isn't the gold standard of proof; its not even bronze. It goes very close to blatantly lying with its headline, and I think its safe to assume that out of everyone involved in determining those results, only the article's author would be so confident about it (at least, as much as he is).

If you're going to cite things, then use things worth citing. In the worst case, read the study itself. But don't go around feeding others such low quality summaries.

As a former smoker, I knew exactly how bad it was for me minutes after the initial high. Smoking is a perfect example, really.
I've noticed that a few minutes after eating some foods (chocolate, unfortunately), I feel like my brain's been messed with. Not in a good way - I'm both mentally a bit off (well, more than normal) and I have a headache.
Would that just be the processed sugar causing a short term buzz though?

I avoid any sugared sodas these days, because I find if I am dehydrated and I drink a canned lemonade etc. I get a headache immediately afterward, with no lessening of my thirst. Plain water or coconut water works best for me.

No. I can eat sugared stuff with little problem. Some specific foods, though, about five minutes later, it's like something kicked my brain. Some others, my brain is just fuzzier for a while.
Are you a coffee drinker? I'm guessing no.

Chocolate contains stimulants theobromine and caffeine. I am not a coffee drinker, nor regular consumer any other stimulant, making me rather sensitive to the effects. If I eat chocolate, particularly dark chocolate, I reliably experience a mild stimulant high.

There's not really a difference between foods containing these molecules and oral drugs containing the same molecules.

Coffee, no. Pepsi, yes (in limited quantities), which at least gives me the caffeine (don't know about the theobromine).

And sure, chocolate gives a bit of a stimulant high. That's part of why we like it. This is something else. It unfortunately comes with certain kinds of chocolate.

Theobromine is vasoactive. The small circulation blood pressure reduction is enough to be felt.

IT is not known to be a headache trigger though, but there are known sensitive individuals.

I was struck by how I started feeling after drinking Diet Coke. It's a rather indescribable feeling of discomfort afterward. The studies about its harmful effects are of no surprise to me.

Same with Ramen. I even experience muscle aching at times after eating it. It's a shame because I find it so tasty!

There is no merit to that approach... it's potentially harmful.

You wouldn't notice the affects of a diet that is devoid of iron for several weeks... you especially wouldn't notice the affects after individual meals. Once you become iron deficient and anemic, you'll start "feeling good" from sugary foods and stimulants that offset the exhaustion from low red blood cells. You wouldn't even feel better from eating iron rich meals until about a week.

There's a similar story for every other vitamin.

Surely there's at least some merit to staying away from food that makes you feel 'strange' immediately after eating it?
That unfortunately only goes so far as to help you avoid (or recognize) food poisoning, and not much more.
Well, I think it also prevents sugar crashes, caffeine spikes and a whole lot of other minor or possibly severe problems.

It doesn't automatically create a good diet, but it's better than nothing. And at least we can both agree that it's effective, which is more than you can say for some of the nutrition advice out there.

Unless there is a case where feeling weird is actually a good thing, but I can only come up with fairly extreme examples where that would be the case, which comes closer to medicine than nutrition.

A good point about sugar. Sugar’s interesting, though, in that it produces a kind of euphoria before it results in the feeling of crashing (usually moderately long afterward). For that reason it can be difficult to correlate the feeling of crashing with the consumption of sugar, but relatively easy to correlate sugar with the good feeling.

Off-hand I can’t think of any food that produces an immediate and significant bad feeling unless it’s rotten, spoiled or otherwise intolerable.

There is almost a 0% chance that the GP, as (presumably) an educated and well-fed citizen of a first-world country, has a serious vitamin deficiency. That's not the failure case that he's avoiding. My guess would be that that "weird feeling," in most cases, is a sugar rush from eating something with a high glycemic index; do that a lot [1] and it puts pressure on your liver and kidneys and otherwise causes non-optimal results. Not as serious as an iron deficiency, certainly, but worth paying attention to.

[1] Most people do. White bread has a high glycemic index.

Industrial food products are engineered specifically to make people feel good in the short-term. If these are in your repertoire of eligible foods, I don't think your strategy is particularly good.
Yea, food engineering is particularly problematic.

If you are going to scientifically remove all the fiber from a food item, then boost its calorie content even higher with added sugars and oils, don't be surprised when people gain weight.

Fiber is a huge hunger modifier. It's hard to overeat 'bulky' lower calorie foods. The fiber takes longer to digest, and doesn't complete the digestion process until the small intestine giving the feeling of fullness longer than something made out of simple carbohydrates.

But hey, letting Conagra sell bright colored sugar at the lowest subsidized possible price is the American way!

I feel like I know when I've eaten something unhealthful. Even feeling it in my burping afterwards feels like an indicator to me. I don't generally feel this way after a salad or drinking water.
Nutrition research is really difficult; lack on immediate reactions (digestion and metabolism take time), highly variable results because on stimulus in other parts of the body (including stress) and its being ethically impossible to have a control group (locking people in a room and feed them one this isn't realistic anyways).

On the curve of "knowing how much we don't know" we're just realizing this is way harder than anyone expected even a few years ago.

Don't forget different gut bacteria. Different people may well respond to the same food in different ways.
Totally. I signed up for the Kickstarter of uBiome years ago who's market line evolved from "We'll figure out a 'normal' biome and help you get there" to "Turns out there is no normal, let's try grouping people" to now something around "OMG this stuff changes constantly! We're going to go science for a few years and get back to you latter with something".
And intestine length
Look at https://nutritionfacts.org it's a doctor that does the digging through research paper and try to find a place to draw the line. Spoiler: The best diet is complete avoidance of process food and animals products. It also correlate highly with the blue zones findings.

edit: wow! I was expecting some pushback, but this is still a surprize. Please take a bit of time to look at the actual content before being to critic. Also it's made to be a bit entertaining and simple so it can reach a larger audience.

It also completely ignores any science that goes against vegan orthodoxy. So, take it with a very large grain of salt (and a slice of bacon).
I would like veganism a lot more if so many of its representatives didn't act like it's a cult. The moralizing, in ingroup/outgroup dynamic etc.
Do you have exemples, I think he his genuinely concern by the health of people, but I would like to see some counter arguments.
Here’s a point-by-point takedown of many of Greger’s antiscientific claims: https://sciencebasedmedicine.org/death-as-a-foodborne-illnes...

The fact is, Greger is not a scientist. Science requires honest investigation, and a willingness to update one’s beliefs. Greger is an activist — he has already decided what his beliefs are, and he is selectively choosing to emphasize studies that support his beliefs (while ignoring those that don’t).

I wouldn’t have a problem with this if his site was called veganopinions.org. You’re allowed to have beliefs based on morality, not science. But when you corrupt the science to advance your cause, you’ve lost me entirely.

Thanks, I will have a look. I find too that his conclusions seems skewed in that direction. My other reference for alimentation was the blue zone that also pointed mostly in the same direction, no process food, plenty of vegetable or vegan but also in some case a bit of meat and cheese.
My problem is that I don't know what exactly constitutes "processed food". Like, isn't cooking a steak on a pan constitute a "process" on a food? If processed foods don't consider my steak example, how much process on a food causes it to fall into the unhealthy category you are describing?

I'm not trying to be nit-picky, this seriously is confusing for me (probably no small-part due to marketing).

What I think is generally meant by "processed food" is processed prior to your acquisition.

But you're obviously capable of doing any number of harmful processes on your own, it's just somewhat unlikely. Most people aren't incentivized to process their own foods for optimal shelf life and profitability over nutrition and health.

My personal rule of thumb: if it wasn't available for pre-agricultural human, it doesn't have to be part of your diet (doesn't mean you can't eat it at all, but you surely shouldn't make it the foundation of your diet).

Dead animal and the fire are definitely part of Homo, especially Homo Sapiens.

You can call that a Paleo diet if you will, I don't, as the term as been tainted by quackery (see also: Superfood).

"does the digging through research paper and try to find a place to draw the line" < That's not science, that's literary interpretation plus tendentious guess work.

"animals products" - We have been omnivores since before the genus Homo evolved. Our physiology has evolved to extract nutrition from animal products efficiently. A herbivore diet isn't sufficient for our species. Even our closest relatives, Chimpanzees, eat meat.

> We have been omnivores since before the genus Homo evolved

So? Evolution doesn't optimize for the lifespan we're targeting currently.

Please take a look at a few of his video, you will see. If for exemple you look at the antioxidant effects in blueberries there is probably hundreds of published papers. If you want to explain the scientific consensus in a few minutes video so people can take action in their food choice you need make some simplifications. Also, you might need to discard the papers that got financed by the blueberries association if their finding are wildly differents than the general consensus.

And by all mean, you are still free to read all the papers if you have the time, but that is probably a one man job just for the blueberries.

That site looks like spam - long form copywriting in video format - driving visitors toward buying his books.
See http://fivethirtyeight.com/features/you-cant-trust-what-you-... for a bit more serious coverage.

OT, it's always surprised me with the diversity of pets people buy that these animals can generally eat the same thing for every meal, while humans can't.

We could, but food is basically a defining characteristic of human culture. Food comes in such an amazingly varied myriad of flavors, textures, temperatures, methods, spices, etc. I think at this point we've evolved such that for some 99.9...9n% of us, we literally can't eat the same thing every day. It would suck one of the simple joys of life out of our lives.
We do not even know if we feed the pets a healthy diet because nobody cares. Some think they know what constitutes a healthy diet for humans but there is very scarce and conflicting evidence except the grandma advice of "eat your greens". And not with big effect sizes either.

Not "be vegan or vegetarian" mind you.

The fun part is that humans are likely much more adaptable in terms of diet than other animals.

We do not even know if we feed the pets a healthy diet because nobody cares

I think people care more about their pets diet than their own

I think we know a lot more about what to feed animals. There are several reasons for that: It is not considered unethical to do large scale experimental studies on animals. Most domestic animals have much shorter lifespan than humans, so it is possible to study the effect of different diets through a full life cycle. Finally, there are strong economic incentives to produce the meat with desired qualities, the most amount of milk or the highest quality of fur with the most cost effective diet possible.

For example pig farmers have known forever that if you want to have fat pigs you feed them grains, and if you desire lean meat you feed them high protein fodder.

The article is a bit hyperbolic. Nutrition is complex and hard-to-study, the research is under various distorting pressures from several industries, and it's been gotten disastrously wrong in the past, but such is science- science is hard. Just because we've gotten it wrong before doesn't invalidate more recent results, and just because there are important uncertainties in our current knowledge doesn't mean we can't quantify and manage that uncertainty.

The real issue is, and the author's real point (whether he knows it or not), is that non-scientists don't, and currently mostly can't, know anything about nutrition. To get a decent, self-respecting nutritional fact, you need to trace it back to the studies (to make sure it's not corporate BS,) make sure these studies are relatively recent (so that they're not deformed by the various assumptions and flawed conceptual frameworks that dominated the field a couple decades ago,) and ensure that the researchers and statistics at work are reasonably trustworthy (to make sure it's not some of the bad research that is still being done[1].) This is not something that most people can do, and that's simply to access the limited and uncertain facts we currently have. To the typical highschool graduate trying to make dinner, it's worse than useless.

([1] Which is, again, not unique to nutritional science. Bad papers are published in every field.)

More than a lack of knowledge, we have a lack of trustworthy authority. If someone wants to know about chemistry or math, trustworthy sources are easy to find, and their pronouncements can be taken on faith if the student doesn't want to get bogged down in the details. If someone wants to know next week's weather, the available answers will be uncertain and untrustworthy, but everyone at least knows the right people to ask, and has some idea of how to deal with "50% chance of rain." In nutrition, no one knows where to ask, and no one knows how to deal with what information that is available (for instance, raise your hand if you know the glycemic index of your most recent meal.) The answer to this can't be the scientific method; it's a social process.

Incidentally, the present nutritional wisdom is probably best summed up by Michael Pollan's "eat food; not too much; mostly plants." From that you'll be fine. (If you want to be really fancy, know the calories-per-serving of the ~10 most common foods you eat; by then you'll be eating healthier than about 95% of Americans, most likely. Know the glycemic index and you're past 99%.)

The only advice that makes sense, and for the past half century or so has been constant, albeit hiding in plain sight under whatever the fads of the day are:

Exercise regularly. Avoid extremes in diet - but eat a bit of variety. Get the minimum recommended amounts of vitamins and minerals. Keep your calories and your body fat low.

And if you have bad genetics, you're probably just screwed, and no amount of exercise or diet will fix it.

A more fashionable alternative of variety is diversity.
There is no evidence (known to me) that variety is actually beneficial. (Past the obvious "get known required amounts of vitamins and minerals")

There is some evidence that certain kinds of atypical diet are slightly less beneficial in terms of mortality. (Low carbohydrate long term. Cause unknown, not CVD or cancer. Very good review, thoroughly recommended. The key word is "all cause mortality and morbidity") And the varied (in certain ways) Western diet is also shown to be quite bad.

Please correct me if I'm wrong, I like to review nutrition papers fairly and thoroughly but have never seen one on this...

In the absence of hard evidence, by avoiding variety, you're probably more likely to miss consuming an essential or beneficial food than you are to eat something that is bad for you in large amounts.

Variety in moderation seems to be the only effective proxy to smooth over the constant "used to be good for you - nope, not any more - wait we were wrong it is good" oscillations.

I mean a variety of plant and animal sources, and a variety of macronutrients - to cover all the bases. With the exception of trans fats, and possibly red meat, nearly every food seems to be safe in moderate doses, so there's no reason to avoid or load up on anything in particular.

And when they find out that something like, for example, oily fish, is beneficial - you can look back and say hey, I ate a bit of that too.

I agree that not all forms of variation are good, but variation within what mainstream nutrition science recommends at this point probably mostly is.

tl;dr - no one really knows anything, so play the odds.

> Keep your calories and your body fat low.

This is a bit like financial advice stating "don't become poor" or health advice stating "don't get cancer".

It’s like financial advice stating that you shouldn’t spend more than you earn. If you are in debt, spend less money. If you are overweight, eat less food.

Of course both of these advices are easier to follow for some people than for others.

No, it's not.

Exercise and/or don't stuff your face. Pretty simple, really.

And, unlike your finances or genetic predisposition for cancer, you have total control over it. No one is forcing you to over eat.

An article like this is the same type of disinformation it is railing against. Sure the government backed food pyramid and now food plates are terrible (and there is a conflict of interest), and private studies are often no better.

But we don’t know anything about nutrition? What about the Krebs Cycle? I think that is good science right? Cellular health and energy production aren’t exactly controversial. How many people are arguing that inflammation in the body is good or promotes health? Does anyone suggest insulin spikes are good?

Unfortunately you can’t name the foods that cause inflammation or insulin spikes...because that’s when there is push back, but we all know what they are and we don’t need to name them, because there is consensus those things are detrimental to health, which should be the focus of nutrition.

Actually evidence is trending towards saying that inflammation is good for healing, and that taking NSAIDs is counterproductive.
I don’t think I mentioned inflammation as a natural function of healing nor did I mention NSAIDs vis-a-vis inflammation as a natural healing process of the body. From your context it sounds like you are talking about natural inflammation from things like working out (muscle tears) and NSAIDS interfering with the natural muscle repair.

Obviously I am discussing inflammation in the context of diet. Though if I’m mistaken, please link a study that suggests dietary inflammation is good for healing. I’m sure instead you will find articles and studies about dietary inflammation putting the body in a state of chronic inflammation which isn’t going to be beneficial for any healing process.

> What about the Krebs Cycle?

So if you look at the [Big Picture of the metabolic pathways in humans](http://biochemical-pathways.com/#/map/1)... what do you have?

Fuzzily defined, extraordinarily complex tangle with feed back loops all over the place, some going through that amazing tangle of the brain.

If you were to translate this into a mathematical model and look at it from a purely mathematical perspective (even if you omit the parts involving the brain).

It's a highly non-linear system of Partial Differential Equation's with many variables and a bunch of fuzzily measured constants.

And then you compare it with a really really simple setup like, say, [3 bodies acting under gravity](https://en.wikipedia.org/wiki/Three-body_problem). You know, something almost as simple as it gets.

Way way way simpler than the metabolic pathways in humanity.

And we know from a purely mathematical point of view.... that except for a very very tiny set of special cases, we haven't clue what will happen with the 3 body problem.

So yes, the article is spot on.

In terms of individual chemical reactions, we have some ideas.

In terms of dietary advice to individuals or populations... We floundering and should admit it.

This is spot on. These are chaotic systems we're talking about, in our very bodies. Not only that, these systems are literally embedded in our very senses. In many very real ways, they are the medium of our senses.

Because of this, I strongly disagree with the following statement:

> We’re pretty darn sure no one else knows anything about nutrition, either. Please don’t listen to “alternative” nutrition quacks. We’ve been there, and we know.

The reasoning goes like this: "if we can't figure this stuff out, no on can!" That's sheer hubris. These kinds of systems are sometimes best tackled with idiosyncratic methods.

Well, that's false. The reality is that everybody knows about nutrition, otherwise they would die. Nutrition is an evolutionary, messy, irrational art-science.

It's just important to understand that everyone's body is a unique, multifaceted universe of sorts. What two people have in common, nutritionally, could be totally off for a third person.

"And we know from a purely mathematical point of view.... that except for a very very tiny set of special cases, we haven't clue what will happen with the 3 body problem."

Yet there are dancers who perform spectacular 3 person pieces all the time. Go figure! That should be "impossible" but it's not. Because life is infinitely more nuanced and wondrous than closed-minded "scientists" want (you) to believe.

Obviously the quacks cannot figure things either. Otherwise they would have actionable evidence of good statiatical quality. Scientific method (esp. RCTs) provides actionable evidence.

Just be careful whom you call a quack... dietetics has way too many facets that are being analysed at the time.

We also have science that works quite well on unknown systems - epidemiology and statistics.

While it is not good enough to figure out causes, correlations are good enough in typical cases to be actionable.

The strongest one we have is "eating plenty of greens and raw vegetables will make you look like other healthy people". I haven't seem any contravening evidence to this very not ground-breaking conclusion. The problem is that it flies in the face of 70 years of dietary recommendation (which was grains) and in the face of all the industry (because it is not shelf stable).

Exercise so far while improving health in the elderly has not been linked to persistent weight loss.

I could be more specific about thresholds there as well. (In terms of volume.) Butt what good does it do? These are fuzzy thresholds.

Them we have evidence that high fat diets are effective at weight loss (about the same as low fat diets) but some that they have no other health effects that are not really explained by weight change. Thus the diets are not specifically recommended, one over another. Even the high fat diets resulted in caloric restriction.

The long term analysis gives slight but existent increase in all cause mortality that is not explained by CVD mortality nor cancer. Thus we do not know the cause. Quacks like to tell that they know the causes.

Or other that any kind of diet is somewhat effective so the right placebo in weight studies is regular weight monitoring. Not no diet.

And a lot of evidence that people cannot really self regulate to health with bad substrates.

> Just be careful who you call quacks...

I just really don't care for the term. It's derogatory. Since when did a derogatory term have anything to do with science? I've studied science all my life, and I've come to the conclusion that I'd rather be personally called a quack pseudo-scientist than ever find myself calling other people quacks for having the courage to stick with unconventional or marginalized ideas.

Here in the U.S., anti-fluoridation activists have been labelled "quacks" for years. But the evidence keeps flowing in that too many fluorine ions in your body can cause trouble, especially if you're a developing embryo or child. It even seems that the evidence has been actionable, since in 2015, the DHHS cut the maximum recommended water fluoridation level in half. The DHHS maximum limit is now 0.7 mg/L, but the EPA's "enforceable standard" is 4.0 mg/L. ?

But anti-fluoridation activists activists are still being called "quacks" to this day.

> Does anyone suggest insulin spikes are good?

Actually nice "case in point".

I have seen evidence presented that it's not the spikes that are the problem, but the "area under the curve".

ie. An insulin spike is just the body doing what it should, keeping the blood sugar in bounds.

However, it's how long times it goes on for times how high that does the damage (to an obese person).

ie. Nutrition science is packed solid with fine fine print and noxious little interactions and feedback loops.

Very little of which fits in a Cosmo magazine sound bite or is applicable to a general population.

I just think it's kind of amusing that a large number of comments on this post are (unironic) personal anecdotes arguing as to why their particular diet plan is the best.
A bit too late for April fools, no?

Otherwise it's just shameless praise to ignorance. (The good ol' fallacy that if you can't get it 100% correct for everyone, then might as well not even try)

The weightlifting crowd seems to have figured out nutrition for themselves just fine. So have millions of fit, active people.

Nutritionists may be quackery as a job/profession, but nutrition is still a valid part of biology and a science.

Diet/study says that if you do X you will lose weight because of Y.

You do X and lose weight.

The error is thinking that you lost weight because of Y, and not because of a secondary unlisted effect of doing X.

The same applies for certain diets/organisms causing conditions/diseases/etc. i.e. the whole cholesterol back and forth.

We've learned lots from nutrition and in general informed people live healthier lives. Just because we don't know exactly what's going on inside our bodies doesn't mean that zero improvement has been made. We'll fuck up once in a while and get some bad advice, but in general we've improved lots.

The annoying thing is we seem to be getting fatter and no one seems to be able to nail it down.
No, that is nailed down. We eat more calories and we do less. We eat out more and restaurants are economically motivated to sell larger portions because people feel it is a better value. There are more high calorie snack products available in more places for lower prices than ever.

Education mostly doesn't work. Most people can consume huge amounts of sweet/fat/salty food, far beyond there caloric needs, even when they know it is bad for them. Maybe the small portion of humanity that can execute portion control inherits the Earth. Maybe we lock down businesses freedom to pettle crap foods to addicts. I'm not sure what the answer is.

I'm all the way over zealous rationalism.
I think the problem here is a lack of tools. PG often says that the smarter people must build tools for the dumber ones. I have never met a smart RDN. They have no tools to do the research into our diet and its impact that is really needed to create a meaningful impact.

Full Disclosure: I am currently building these tools.

No, the problem is we don't fund enough nutrition research because the only people who benefit are non-corporations. Your liver does not have a lobbyist. For God's sake the director of the CDC had to resign because she didn't want to jettison her tobacco investments. There's only one political party responsible, and before the right-wing moderators here ban this comment, let's just say we need to pay attention to who we put in charge in this area.
Indeed the really important question that is slowly being dug in (too slowly in my books) is how a quite strictly testable thing as nutrition science has failed to produce truly actionable results. With at least decently described applicability.

Maybe it is because of outside influence, maybe it is due to much to broadly asked question and/or premature generalization. Or following leads without actually testing their veracity, which probably has another cause.

Maybe partly ethics preventing us from experimenting on ourselves as a species in a rational way. (Unlike the random uncontrolled irrational experiments we run every second of our life.)

Glory, finding or requirement to prescribe action even if we do not know what should be done. Also known as leadership in some circles...

It is strictly testable in principle, but not really in practice. You can't exactly lock up people in a metabolic ward for years to collect long term data.
I grew up in the Deep South. Most of my family members are morbidly obese and have diabetes. I avoided this by spending hundreds of hours reading and thinking about nutrition. Here are my ground rules for healthy living:

1) Drink a lot of water everyday.

2) Calories are the most important baseline measure that affect your weight.

3) Walking for 20 minutes a day will give you 90% of the exercise you need. Go for a walk after lunch with your colleagues!

4) Don't trust food scientists, including ones that work for the government. They are paid to sell more food.

5) Putting vegetables on pizza doesn't make that pizza healthier. It may make it "less unhealthy". Think in terms like that.

6) The more synthetic a food is (i.e. the more processed it is), the more unhealthy it is. Human evolved to eat a certain way -- remember that. Use olive oil, real butter, etc. Eat whole fat everything.

7) Eat a lot of vegetables. Don't eat a lot of red meat. Yogurt is really good for your gut.

8) If you're going to eat something unhealthy, embrace it! Acknowledge that you are treating yourself.

9) THINK about your diet. Evaluate how you feel.

10) Look at your body in the mirror more than you step on a scale.

Good list, but I'd suggest to leave out dairy, there are better alternatives on many levels.

Check out this talk by Dr Neil Barnard https://youtu.be/v_ONFix_e4k

All of the alternatives to milk, cheese, yoghurt and so on are woefully inadequate in nutrients. Primarily protein (although soy is decent there), but also in vitamins and minerals. Yes, even enriched varieties.

11) Don't trust anything you hear in a TEDx talk.