My advice is to do searches of your interested... Find people who talk about what you care about; even more importantly, people who interact with their followers. It all depends on what you care about.
Felicia Day (@feliciaday). She's a celebrity whose life is nothing like mine, and yet her tweets are the most sincere and down-to-earth of nearly anyone I follow. Her tweets put things in perspective.
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[ 2.8 ms ] story [ 14.8 ms ] threadhttp://jeffmiller.github.com/2010/07/28/twitter-users-most-f...