> CGRP has been shown to activate the mitogen-activated protein kinases (MAPKs), which are phosphorylated in some tissues following CGRP activation. This can lead to the proliferation of gingival fibroblasts (215), via PKA-dependent and -independent pathways (214). CGRP can protect cultured vascular smooth muscle cells from oxidative stress-induced apoptosis by a signaling pathway involving activation of extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 MAPKs (354).
To simplify, migraines are a result of oxidative stress, and CGRP helps reduce oxidative stress. Seems a bit reckless to me to be decreasing CGRP
Anecdotally, while I've never had a proper migraine (but my mom does occasionally), I used to get terrible headaches. I've completely eliminated this by eating an anti inflammatory diet and taking a collagen supplement. Glycine is the main amino acid in collagen, many (most?) people are deficient, and is used to make glutathione, you body's natural antioxidant and detoxer.
My wife is a lifelong migraine sufferer and these anti-CGRP drugs really seem to be working (fingers crossed). She'd literally tried everything and had given up. Virtual high-five to these researchers
Decades of migraines. I know know now that mines are directly related to my diet, although stress, breathing, posture, sleep, screen time and lack of exercice are all aggravating factors.
But food is the trigger. Regular important quantity of sugar or milk can trigger it. A huge meal as well. Something very hard to digest aw well.
But here is what prevented me make the link between food and my head exploding for all those years: it can takes up to 48h between the trigger consumption and the start lf the pain. Also, the trigger is the straw breaking the camel back, but it can take some time to eat again and again the same thing before reaching the tippung point.
Once I realized that, a diet journal was enough to notice trends and understand what my body reacted to.
I don't think all migraines are food related, but it's worth investigating given the handicap real migraines are in ones life.
The only thing that makes me survive migraines is marijuana, I've tried a ton medicament and all of them make you feel dumb or sleepy, with a good hybrid weed you can do almost anything.
I wish they would focus more on what causes these symptoms rather than on pain control.
I began having migraines in my early thirties. My mother was a long time sufferer. Coincidentally, a few months before I began having them, she told me birth control pills had caused hers. I was having them the three weeks of the month that I took the pill and not having them the week I was off the pill to menstruate.
When I went for a refill, they didn't have my usual brand available. My headaches temporarily went away, but soon came back. With this additional piece of evidence, I concluded the pill was indeed the most likely cause.
I informed my husband that I would complete the pill packets I had on hand, I think three months worth, but I wasn't getting my prescription renewed. So we had three months to come up with some other birth control method.
I went off the pill and the headaches promptly cleared up.
I'm sure there are myriad different things that can cause a combination of headache and nausea. If you can figure out the cause for the person in question and treat that, it's a vastly superior solution to pain management type approaches.
Also, the light and noise sensitivity mentioned in the article is something I successfully treat as a symptom of magnesium deficiency by upping my consumption of magnesium rich foods. I routinely get such symptoms following fever or vomiting and they are readily cleared up by improving my magnesium status.
I didn't invent that solution. I learned it from an internet forum. It has worked consistently for me for years.
I used to have migranes every two weeks on average but they stopped when I switched from a western diet to pure vegetarian ("vegan") diet some time in May last year. I'm not 100% certain it's the diet (how could I be?) but I can't ignore the causality.
12 comments
[ 4.2 ms ] story [ 42.7 ms ] threadI need a vacation!
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187032/)
To simplify, migraines are a result of oxidative stress, and CGRP helps reduce oxidative stress. Seems a bit reckless to me to be decreasing CGRP
Anecdotally, while I've never had a proper migraine (but my mom does occasionally), I used to get terrible headaches. I've completely eliminated this by eating an anti inflammatory diet and taking a collagen supplement. Glycine is the main amino acid in collagen, many (most?) people are deficient, and is used to make glutathione, you body's natural antioxidant and detoxer.
But food is the trigger. Regular important quantity of sugar or milk can trigger it. A huge meal as well. Something very hard to digest aw well.
But here is what prevented me make the link between food and my head exploding for all those years: it can takes up to 48h between the trigger consumption and the start lf the pain. Also, the trigger is the straw breaking the camel back, but it can take some time to eat again and again the same thing before reaching the tippung point.
Once I realized that, a diet journal was enough to notice trends and understand what my body reacted to.
I don't think all migraines are food related, but it's worth investigating given the handicap real migraines are in ones life.
I've never found the current drugs more helpful than a Tylenol.
I began having migraines in my early thirties. My mother was a long time sufferer. Coincidentally, a few months before I began having them, she told me birth control pills had caused hers. I was having them the three weeks of the month that I took the pill and not having them the week I was off the pill to menstruate.
When I went for a refill, they didn't have my usual brand available. My headaches temporarily went away, but soon came back. With this additional piece of evidence, I concluded the pill was indeed the most likely cause.
I informed my husband that I would complete the pill packets I had on hand, I think three months worth, but I wasn't getting my prescription renewed. So we had three months to come up with some other birth control method.
I went off the pill and the headaches promptly cleared up.
I'm sure there are myriad different things that can cause a combination of headache and nausea. If you can figure out the cause for the person in question and treat that, it's a vastly superior solution to pain management type approaches.
Also, the light and noise sensitivity mentioned in the article is something I successfully treat as a symptom of magnesium deficiency by upping my consumption of magnesium rich foods. I routinely get such symptoms following fever or vomiting and they are readily cleared up by improving my magnesium status.
I didn't invent that solution. I learned it from an internet forum. It has worked consistently for me for years.