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Two things:

Should it matter is not the right question. The science will tell us, and understanding differences among people is never a bad thing. We are all different.

Celebrate that, work to mutual respect and understanding and equality in terms of gender role freedom. In my view, that is the outcome of successful feminism.

Do the brains of trans people change over time once they transition? If so, we have an opportunity to get otherwise hard to get data. They will go through experiments, of a sort ethics would very clearly bar (and should), as they seek harmony between mind and body.