When you want to use external caching mechanism (outside the JVM), serializing/deserializaing of objects introduce a penalty. A good serialization library makes the external cache more viable.
Be careful with these. I recently found that Java serialization is much faster for large integer arrays than packed repeated int32 fields in protobuf. For most clients, this speed wouldn't matter, but for me I actually had to stuff the java serialized bytes into a protobuf bytes field.
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