Markdown can do much more than GitHub readmes (blog.esciencecenter.nl)

There's several use-cases listed where Markdown could be used for, such as paper writing, presentation etc (I'm not sure I am going to use it for the later in the near future...).

I find that one of the most interesting potential use-cases is in "literate programming" on which the same author wrote another blog post: https://blog.esciencecenter.nl/entangled-1744448f4b9f