I would be interested to find out more about this too simply because MOOCs tend to attract people who are looking for hyped-up topics and taking shortcuts in a more general sense, while this topic is the opposite in many ways.
Udacity courses on high performance computing are good MOOCs [1][2]. Also MIT's Computation Structures course [3] covers some quantitative performance modeling.
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You can also try searching for classes entitled "Advanced Computer Architecture" like so:
http://www.sci.tamucc.edu/~sking/Courses/COSC5351/syllabus.p...
I'd also check out Berkeley's FireSim tutorials and community
https://fires.im/
Best of luck! There is no down side to mastery of these dark arts ;)
[1] https://www.udacity.com/course/high-performance-computer-arc...
[2] https://www.udacity.com/course/high-performance-computing--u...
[3] https://computationstructures.org