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A great Manga with a premise centered around trepanation is Homunculus by Hideo Yamamoto
Wait, so does it have noticeable effects on consciousness? I wish the article had described the perspective of patients. What does it feel like?
If you're interested there are articles about people who tried themselves or with the help of friends at home, in the 70's or so. I read about it a while ago, but although it's an interesting read there's no clear answer (people were already into it enough to perforate their own skulls, so their account isnt very subjective, and they were usually into the paranormal, "energies" and similar pseudoscientific ideas).