The topic of epigenetic clocks is extremely interesting for me. A clock called GrimAge [0] is already capable of predicting lifespan, time-to-cancer etc. better than normal chronological age. It even seems to work for other mammal species [1]. The big question is: is methylation of DNA only a marker, or does it play some functional role in aging.
This video contains a new bit of information: when they fixed methylation patterns in experimental mice, the therapy failed. That would hint on a functional role of DNA methylation in the process of aging.
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[ 3.3 ms ] story [ 17.0 ms ] threadThe topic of epigenetic clocks is extremely interesting for me. A clock called GrimAge [0] is already capable of predicting lifespan, time-to-cancer etc. better than normal chronological age. It even seems to work for other mammal species [1]. The big question is: is methylation of DNA only a marker, or does it play some functional role in aging.
This video contains a new bit of information: when they fixed methylation patterns in experimental mice, the therapy failed. That would hint on a functional role of DNA methylation in the process of aging.
[0] https://pubmed.ncbi.nlm.nih.gov/30669119/
[1] https://www.youtube.com/watch?v=paiw4QSOtzg