Ask HN: Question about mRNA Vaccines?

Yeah, I saw that one. But the cohort of patients it's talking about already have autoimmune issues and the focus is on the adjunctives.

I think there was another one talking about 50% of severe covid patients developing autoimmune antibodies, but with no idea if they will progress to a condition.

I was hoping to see some longterm studies from prior mRNA research. But it's my understanding that the longer research wasn't about inducing immune response but for trying to modify DNA to correct genetic conditions (which failed, but now crispr...).

I'm asking for stuff like PubMed studies. I just want some more info about this stuff. I don't really care about the stuff being talked about in the media, because it's generally not crediable (at least in the way they tend to present it). This question was something I thought of on my own and was curious about.

There are claims in the media on either "side" that are unsubstantiated or not true. Take your statement about groups saying the vaccine is dangerous. There are also groups pushing for everyone to get the vaccine, even for children. So far the data shows that it should be generally safe (as other approved vaccines are), but that there could be some risks (also true with other vaccines). But we still don't have all the data (looks like Pfizer will apply later this year). What this means, is that it's difficult to perform an objective risk/benefit analysis in age groups which have extremely low hospitalization rates (like kids) as it could take even a very low severe adverse event rate to outweigh it. The risk/benefit becomes much clearer in some other age groups with high fatality rates (80+ yo). For example, it would be much easier to find a severe adverse event that effects 5%+ of that population, and any rate below that is still a net benefit considering that age group has a 5%+ fatality rate. Not to mention, the likelihood of negative effects being discovered decades down the road (like autoimmune stuff) doesn't really matter due to the constraint of expected lifespan.

Thanks for sharing this thought, very interesting.

I think we can't say which effects are at play here though without waiting for more numbers. Next to reports in e.g. VAERS; by now there are many reports by different real user accounts from different nations reporting severe side effects and deaths. There is a lot of tribalism, totalitarianism and unscientific overconfidence from those who decided for the vaccine as well. For them such reports are either pure statistics of large numbers (which I agreed with at first but wouldn't be so confident about anymore) or collateral damage (which is extremely cynical, given that the damaged people are often young and healthy without high risk from covid and just "wanted to do the right thing" or get certain freedoms back).

A less severe but suspicious and little explained side effect - the menstrual issues - are quite widespread, but are dismissed as hysteria..