Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory [1]
Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson’s Disease [2]
It's exhausting because the stories exaggerate the findings. Most everything in science is nuanced. Small sample, preliminary finding, caveats, unclear results…
Really, this is more of an issue with modern storytelling which is often motivated to be sensational, or at least to present a relatable story.
Or in this case a meta study. It's hard to say how meaningful the results are because the purposes and methods of the underlying studies, meaning it's not likely they were designed to control for other factors that would impact what this study was looking at.
If this is significant, then maybe one should refrain from keeping a phone near testicles for a month or two before using those testicles for procreation. Otherwise, not terribly relevant to behavior.
I know. The headline is still wrong. Aspirin may improve one’s chance of living more than five years with cancer. Everyone will die, with or without cancer, with or without aspirin.
Risk (a chance of an adverse event) of death always approaches 100% given enough time. Eventually the set of all possible events that can happen to you is smaller and smaller, and proportionally more of the probability space is occupied by events that lead to your death.
I understand the point of the article and the hundreds of other like it proclaiming coffee or red wine or friends reduce the “risk of death.” They mean to say reduces the number of test subjects who died during the study period. Nothing reduces the risk, though. We all die.
This is likely good news, but it’s important to understand context.
In yet another case of optimizing for a metric, 5 year cancer survivor rate used to roughly equate to a cure. However, as more people are living longer in treatment with cancer, many things that only slightly slow death can look awesome while only adding a few months on average.
For something as cheap and side effect free as Aspirin it’s likely an obvious choice. Just don’t except long term survival odds to improve as much as suggested.
I have been taking baby aspirin since I had a colon cancer scare after my doctor advised me to. After a lot of literature reading, daily low dose aspirin therapy seems to be a good way to take care of your health.
Mesalazine aka 5-ASA is an medication used to treat ulcerative colitis, crohn's and co. It's molecule is very similar to Aspirin. In fact, mesalazine is basically a localised form of aspirin for the gut. That's the logic I see in my head
I take 100mg almost daily myself, but some studies say that for people without a prior stroke, myocardial infarction or Angina pectoris it can even be harmful.
[1][2]
According to most general physicians here in Germany I shouldn't be taking it as a person without said medical history.
I don't plan to continue taking daily Asprin when I have met my weight loss and exercise goals.
This new evidence for benefits with cancer patients is very interesting.
Studies like that are hard to judge as a layman, meta-studies even more so.
[2] found:
> Cancer was the major contributor to the higher mortality in the aspirin group, accounting for 1.6 excess deaths per 1000 person-years. Cancer-related death occurred in 3.1% of the participants in the aspirin group and in 2.3% of those in the placebo group
In addition there's the risk of gastrointestinal bleeding.
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[ 0.22 ms ] story [ 112 ms ] threadIt should also be trialed against Triflusal, which an COX-1 irreversible inhibitor that is safer in some circumstances.
https://en.wikipedia.org/wiki/Triflusal
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931664/
[1] https://doi.org/10.1073/pnas.1802021115 [2] https://doi.org/10.1007/s11481-018-9808-3
It is purposefully not a like or upvote or a bookmark – it is a declaration of importance of the parent comment.
https://www.healthline.com/health-news/a-low-dose-aspirin-da...
Really, this is more of an issue with modern storytelling which is often motivated to be sensational, or at least to present a relatable story.
https://xkcd.com/925/
Correlation != Causation :)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074720/
Edit: honestly, how autistic can one be to vote this down? lol
Every person alive will die, 100% chance.
I understand the point of the article and the hundreds of other like it proclaiming coffee or red wine or friends reduce the “risk of death.” They mean to say reduces the number of test subjects who died during the study period. Nothing reduces the risk, though. We all die.
In yet another case of optimizing for a metric, 5 year cancer survivor rate used to roughly equate to a cure. However, as more people are living longer in treatment with cancer, many things that only slightly slow death can look awesome while only adding a few months on average.
For something as cheap and side effect free as Aspirin it’s likely an obvious choice. Just don’t except long term survival odds to improve as much as suggested.
My intuition says that excessive inflammation, mechanical wear, or other repeated injuries at any scale are cancer/death fuel.
According to most general physicians here in Germany I shouldn't be taking it as a person without said medical history.
I don't plan to continue taking daily Asprin when I have met my weight loss and exercise goals.
This new evidence for benefits with cancer patients is very interesting.
Studies like that are hard to judge as a layman, meta-studies even more so.
[2] found:
> Cancer was the major contributor to the higher mortality in the aspirin group, accounting for 1.6 excess deaths per 1000 person-years. Cancer-related death occurred in 3.1% of the participants in the aspirin group and in 2.3% of those in the placebo group
In addition there's the risk of gastrointestinal bleeding.
[1] https://www.nejm.org/doi/full/10.1056/NEJMoa1803955
[2] https://www.sciencedirect.com/science/article/pii/S221317791...