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"First, unmitigated transmission will disproportionately affect unvaccinated children and young people who have already suffered greatly. ...

Second, high rates of transmission in schools and in children will lead to significant educational disruption, a problem not addressed by abandoning isolation of exposed children (which is done on the basis of imperfect daily rapid tests). ...

Third, preliminary modelling data suggest the government's strategy provides fertile ground for the emergence of vaccine-resistant variants. This would place all at risk, including those already vaccinated, within the UK and globally. While vaccines can be updated, this requires time and resources, leaving many exposed in the interim. Spread of potentially more transmissible escape variants would disproportionately affect the most disadvantaged in our country and other countries with poor access to vaccines.

Fourth, this strategy will have a significant impact on health services and exhausted health-care staff who have not yet recovered from previous infection waves. The link between cases and hospital admissions has not been broken, and rising case numbers will inevitably lead to increased hospital admissions, applying further pressure at a time when millions of people are waiting for medical procedures and routine care.

Fifth, as deprived communities are more exposed to and more at risk from COVID-19, these policies will continue to disproportionately affect the most vulnerable and marginalised, deepening inequalities."

Thinking especially of adverse effects from "Long Covid": https://www.nature.com/articles/s41591-021-01433-3