In Japan, ivermectin has been far less politicized than in the West and there is much more interest in exploring its apparent therapeutic and prophylactic properties:
Way back in the halcyon days of 2017, The Journal of Antibiotics published "Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations" https://www.nature.com/articles/ja201711 . It included the following two paragraphs:
> Recent research has confounded the belief, held for most of the past 40 years, that ivermectin was devoid of any antiviral characteristics. Ivermectin has been found to potently inhibit replication of the yellow fever virus, with EC50 values in the sub-nanomolar range. It also inhibits replication in several other flaviviruses, including dengue, Japanese encephalitis and tick-borne encephalitis, probably by targeting non-structural 3 helicase activity. Ivermectin inhibits dengue viruses and interrupts virus replication, bestowing protection against infection with all distinct virus serotypes, and has unexplored potential as a dengue antiviral.
> Ivermectin has also been demonstrated to be a potent broad-spectrum specific inhibitor of importin α/β-mediated nuclear transport and demonstrates antiviral activity against several RNA viruses by blocking the nuclear trafficking of viral proteins. It has been shown to have potent antiviral action against HIV-1 and dengue viruses, both of which are dependent on the importin protein superfamily for several key cellular processes. Ivermectin may be of import in disrupting HIV-1 integrase in HIV-1 as well as NS-5 (non-structural protein 5) polymerase in dengue viruses.
In Japan, ivermectin is somewhat politicized. Investigating ivermectin is fine, but most anti vaxxer says we don't need vaccine because of ivermectin despite its efficacy isn't proven. Tokyo's Haruo Ozaki is considered to outlier (in bad way).
Vaxed-side is against to overly expect ivermectin's efficacy because it's still not proven and results seems to not quite good.
4 comments
[ 4.3 ms ] story [ 16.9 ms ] threadMainichi Shimbun: ノーベル賞学者・大村智博士が「予防はワクチン 治療はイベルメクチン」Dr. Satoshi Omura, Nobel Prize scholar: "Vaccines for prevention, ivermectin for treatment" https://weekly-economist.mainichi.jp/articles/20210712/se1/0...
Nikkei: 東京都医師会、イベルメクチン投与を提言 重症化予防で Tokyo Metropolitan Medical Association recommends ivermectin administration to prevent serious illness https://www.nikkei.com/article/DGXZQOFB25AAL0V20C21A1000000/
Yomiuri Shimbun: 「今こそイベルメクチンを使え」東京都医師会の尾崎治夫会長が語ったその効能 "Now is the time to use ivermectin," said Haruo Ozaki, chairman of the Tokyo Metropolitan Medical Association https://www.yomiuri.co.jp/choken/kijironko/cknews/20210818-O...
Way back in the halcyon days of 2017, The Journal of Antibiotics published "Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations" https://www.nature.com/articles/ja201711 . It included the following two paragraphs:
> Recent research has confounded the belief, held for most of the past 40 years, that ivermectin was devoid of any antiviral characteristics. Ivermectin has been found to potently inhibit replication of the yellow fever virus, with EC50 values in the sub-nanomolar range. It also inhibits replication in several other flaviviruses, including dengue, Japanese encephalitis and tick-borne encephalitis, probably by targeting non-structural 3 helicase activity. Ivermectin inhibits dengue viruses and interrupts virus replication, bestowing protection against infection with all distinct virus serotypes, and has unexplored potential as a dengue antiviral.
> Ivermectin has also been demonstrated to be a potent broad-spectrum specific inhibitor of importin α/β-mediated nuclear transport and demonstrates antiviral activity against several RNA viruses by blocking the nuclear trafficking of viral proteins. It has been shown to have potent antiviral action against HIV-1 and dengue viruses, both of which are dependent on the importin protein superfamily for several key cellular processes. Ivermectin may be of import in disrupting HIV-1 integrase in HIV-1 as well as NS-5 (non-structural protein 5) polymerase in dengue viruses.
Would you say that ivermectin is politicized in the UK, where this article comes from?
I am in the UK and I would not.
Vaxed-side is against to overly expect ivermectin's efficacy because it's still not proven and results seems to not quite good.
Well, at least it won't be the government itself rejecting vaccines and pushing those drugs...