So you think you have COVID. You're feeling mild symptoms that match the descriptions. Do you (a) take a 3CL protease inhibitor or (b) time travel 6 months into the past and take a mRNA vaccine?
> The drug is effective against a wide number of parasites and arthropods in general [...] It acts most strongly on glutamate-gated chloride channels, which vertebrates don't even have, although it can also bind to other ligand-gated chloride channels at higher concentrations.
Does ivermectin act as an effective protease inhibitor at the clinical dose? There have been some reports of antiviral activities when the concentration is x1000 times the usual dose, but that's a problem. From the same article:
> As those letters to Antiviral Research note, ivermectin will start to hit other targets as you jack up the doses. The reason it's such a great antiparasitic drug is that you don't have to dose up at all. It's hard to imagine that it's a safe compound if you really have to push the concentrations to even within binocular distance of those in vitro levels.
These numbers are not as far off (within a single order of magnitude) as the ones Lowe cites, but definitely outside the realm of "generally considered safe" dose. That's for the mechanism discussed there, where the IC50 was only 2µM.
Translated to the "protease inhibitor" scenario discussed in the video, it's way off. The IC50 there is 21µM. At only 2µM the effect is negligible.
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[ 2.8 ms ] story [ 21.6 ms ] threadhttps://jamanetwork.com/journals/jama/fullarticle/2777389
(Hint: it's probably too late for the protease inhibitor.)
...which is exactly why I'm skeptical about PAXLOVID™
> The drug is effective against a wide number of parasites and arthropods in general [...] It acts most strongly on glutamate-gated chloride channels, which vertebrates don't even have, although it can also bind to other ligand-gated chloride channels at higher concentrations.
Does ivermectin act as an effective protease inhibitor at the clinical dose? There have been some reports of antiviral activities when the concentration is x1000 times the usual dose, but that's a problem. From the same article:
> As those letters to Antiviral Research note, ivermectin will start to hit other targets as you jack up the doses. The reason it's such a great antiparasitic drug is that you don't have to dose up at all. It's hard to imagine that it's a safe compound if you really have to push the concentrations to even within binocular distance of those in vitro levels.
Edit:
I've looked at the link provided:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172803/
These numbers are not as far off (within a single order of magnitude) as the ones Lowe cites, but definitely outside the realm of "generally considered safe" dose. That's for the mechanism discussed there, where the IC50 was only 2µM.
Translated to the "protease inhibitor" scenario discussed in the video, it's way off. The IC50 there is 21µM. At only 2µM the effect is negligible.