Catherine the Great Letter Extolling Virtues of Vaccination Is Up for Auction (smithsonianmag.com)

Luckily she was the head of state. They firebombed the vaccine evangelist Cotton Mather’s house in 1721:

https://www.washingtonpost.com/history/2020/03/07/smallpox-c...

On that note, Catherine the Great had her own husband and several other people brutally murdered to illegitimately usurp the Russian throne and was a terribly repressive and authoritarian despot, even if she liked to claim otherwise.