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How accurate is genome sequencing?

3 points by NiceWayToDoIT ↗ HN
If I take for instance, my blood and give it to two or three different companies to sequence my entire genome, will results of multiple companies match to the letter? Similarly if I repeat sequencing will the one I take today and the one in month after, be the same?

If not, how much is the discrepancy?

1 comment

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nextos
If you get your genome processed into a VCF file, each variant will be listed together with sort of a posterior probability. The discrepancy will be proportional to how stringent your filter is, as variant calling methods are well calibrated. There's a lot of literature on this.