It's surprising how buried any mention of pseudouridine is in the wikipedia article's History section [0], when it's clearly a major component of the mRNA story - 7 years of failures [1] before discovering the uridine toxicity problem. Especially considering TFA describes it's still a point of contention.
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[ 2.9 ms ] story [ 16.5 ms ] thread[0] https://en.wikipedia.org/wiki/MRNA_vaccine#History
[1] https://www.nytimes.com/2022/01/15/health/mrna-vaccine.html