Transhumanism – Philosophy Tube [video] (youtube.com)

I'm surprised that "Rapture of the Nerds" wasn't mentioned around the "uploaded to the (real) cloud" bit...

One (late) 90's scifi work that touches a lot on transhumanism but is more depressing than cheery would be the exoplanetary Civilization video game by a philosophy major : ~~Sid Meier's~~ Brian Reynolds' Alpha Centauri :

https://www.gog.com/en/game/sid_meiers_alpha_centauri

(And also the official game-derived books are downright depressing - though also non-canon.)