Techniques for dealing with lack of motivation, malaise, depression (youtube.com)

Note: This video is from the game developer Jonathan Blow.

https://en.wikipedia.org/wiki/Jonathan_Blow

I didn't watch the youtube presentation. The subject is about depression. I got good results with acetylcysteine (NAC). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044191/