The numbers here seem a bit iffy. While 12 patients underwent the full treatment course with a successful outcome, from the total enrolled in the trial less than 25% reached this state.
It would be interesting to see the reason for the drop-off in the other 39 patients, and for the trial to be replicated on a much wider scale; not to mention, if the method of treatment would be effective with other forms of cancer.
Also worth noting that this was used in conjunction with the standard treatment of chemoradiotherapy and surgery, so with such a small cohort, it's difficult to assess if the PD-1 antibody truly was the key factor in the treatment, or if the standard procedure would have had a successful outcome in each patient alone.
The patients were given a dose of dostarlimab every three weeks for six months. After that, per the original plan, they would be given standard chemoradiotherapy and surgery if their tumors still could be detected. But remarkably, the treatment alone seemed to wholly eradicate their cancer
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[ 3.1 ms ] story [ 15.0 ms ] threadIt would be interesting to see the reason for the drop-off in the other 39 patients, and for the trial to be replicated on a much wider scale; not to mention, if the method of treatment would be effective with other forms of cancer.
Also worth noting that this was used in conjunction with the standard treatment of chemoradiotherapy and surgery, so with such a small cohort, it's difficult to assess if the PD-1 antibody truly was the key factor in the treatment, or if the standard procedure would have had a successful outcome in each patient alone.