Any medical professionals or researchers who can comment on ways to speed up the elimination of oxaliplatin?
44 years (stated as 535 months in the article) for the second half-life, in the body, with the platinum in a reactive form. It sounds like a large reduction in harm could be achieved if elimination could be made to be more rapid especially with oxaliplatin being used to treat the increasingly common GI cancers for people still in early middle age.
The article mentions the oxaliplatin getting bound up in tissues slowing its elimination. Perhaps extreme prolonged fasting to help free some of the platinum up?
The article also mentions sodium thiosulfate to help eliminate cisplatin. Might it also help with oxaliplatin too?
And, there have been many articles about life extension from frequent plasma donation cleaning out accumulated crud from the blood.
I'm wondering if a combination of the above three might help eliminate the oxaliplatin/platinum more quickly. Or, if there is something else that is known to work / that you would hypothesize might work?
Some quotes from the article:
"The first elimination half-life (t1/2) for cisplatin was 5.02 months and the second 37.0 months. For oxaliplatin, these half-lifes were 1.37 and 535 months."
"...it was shown that Pt species in pUF were still present in a reactive form."
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[ 3.0 ms ] story [ 14.0 ms ] thread44 years (stated as 535 months in the article) for the second half-life, in the body, with the platinum in a reactive form. It sounds like a large reduction in harm could be achieved if elimination could be made to be more rapid especially with oxaliplatin being used to treat the increasingly common GI cancers for people still in early middle age.
The article mentions the oxaliplatin getting bound up in tissues slowing its elimination. Perhaps extreme prolonged fasting to help free some of the platinum up?
The article also mentions sodium thiosulfate to help eliminate cisplatin. Might it also help with oxaliplatin too?
And, there have been many articles about life extension from frequent plasma donation cleaning out accumulated crud from the blood.
I'm wondering if a combination of the above three might help eliminate the oxaliplatin/platinum more quickly. Or, if there is something else that is known to work / that you would hypothesize might work?
Some quotes from the article:
"The first elimination half-life (t1/2) for cisplatin was 5.02 months and the second 37.0 months. For oxaliplatin, these half-lifes were 1.37 and 535 months."
"...it was shown that Pt species in pUF were still present in a reactive form."