Totally. You have a base sheet that specifies how everything works, write access limited to developers. Every new players starts by cloning a template that links to the base sheet. It'll have the number crunching of EVE Online with the aesthetics of Dwarf Fortress!
Somebody much more skilled and ambitious than I am once made a working spreadsheet version of the board game Puerto Rico, complete with AI opponents. I think it's still floating around, but it uses macros, so you get all the warnings associated with that.
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[ 4.5 ms ] story [ 35.6 ms ] threadThere's an email there you might reach out to, to see if you can get the full version