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We factorize a 48-bit integer using 10 trapped-ion qubits on a Quantinuum’s quantum computer. This result outperforms the recent achievement by B. Yan et al., arXiv:2212.12372 (2022), increasing the success probability by a factor of 6 with a non-hybrid digitized-counterdiabatic quantum factorization (DCQF) algorithm. We expect better results with hybrid DCQF methods on our path to factoring RSA-64, RSA-128, and RSA-2048 in this NISQ era, where the latter case may need digital-analog quantum computing (DAQC) encoding.