Half the murders in the US are done by black males, basically 600% more than you'd expect if looking at per capita basis, and you want to look into why maga boomers have an uptick in violence (which I somehow doubt is even true)??
I suspect that kind of thing is more common than we realise, but less tied to statins.
People report similar effects with SSRI antidepressants, the contraceptive pill, some antibiotics, some disease modifying drugs, some antiseizure.
It's probably just true that some people react to some drugs with behavioural disturbances. For some reason statins is where people talk about it most. Perhaps because statins are very common and people don't expect a behavioural change, compare that to antidepressants where people quickly stop.
Is it possible to just edit the title to make it clear it's taking about stains?
There is quite a bit of controversy about statins. I believe in double blind studies it's not clear that more report muscle pain than placebo. (The rhabdomyolysis is clearly a possible side effect but distinct from just pain and weakness).[0] The absolute harm difference of 1% translates to a NNH of 100. One person is worse off due to being on a station vs placebo for every 100 prescribed. This NNH is much higher(better) that previously reported.
But are any better off? Ummmm, that's not too clear either it's proven on people with very very high cholesterol over 12 or so not your typical steak for breakfast eater who sits around 6.
Translated into extended quality of life it's probably not much.[1] Your looking at about 1.3% lower risk of death over 5 years mostly in the unhealthiest, exclude those with very high cholesterol and suddenly it doesn't seem so worth it esp if you factor in diabetes and being disincentivized to be healthy.
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[ 4.6 ms ] story [ 31.0 ms ] threadhttps://www.usatoday.com/story/life/people/2019/01/29/empire...
People report similar effects with SSRI antidepressants, the contraceptive pill, some antibiotics, some disease modifying drugs, some antiseizure.
It's probably just true that some people react to some drugs with behavioural disturbances. For some reason statins is where people talk about it most. Perhaps because statins are very common and people don't expect a behavioural change, compare that to antidepressants where people quickly stop.
There is quite a bit of controversy about statins. I believe in double blind studies it's not clear that more report muscle pain than placebo. (The rhabdomyolysis is clearly a possible side effect but distinct from just pain and weakness).[0] The absolute harm difference of 1% translates to a NNH of 100. One person is worse off due to being on a station vs placebo for every 100 prescribed. This NNH is much higher(better) that previously reported.
But are any better off? Ummmm, that's not too clear either it's proven on people with very very high cholesterol over 12 or so not your typical steak for breakfast eater who sits around 6. Translated into extended quality of life it's probably not much.[1] Your looking at about 1.3% lower risk of death over 5 years mostly in the unhealthiest, exclude those with very high cholesterol and suddenly it doesn't seem so worth it esp if you factor in diabetes and being disincentivized to be healthy.
[0] https://www.bbc.co.uk/news/health-54951648
[1] https://thennt.com/nnt/statins-for-heart-disease-prevention-...
They must mean popular prescription drug.