115 comments

[ 3.4 ms ] story [ 27.6 ms ] thread
For those so inclined, Tara Brach had a lovely interview with Roland early this year: https://overcast.fm/+SWwgtYFDM

From the podcast summary:

Meditation, Psychedelics, Mortality: A conversation with Tara and Roland Griffiths - Roland is a long-term meditator, a psychopharmacologist and professor at Johns Hopkins, and a leader in researching the clinical effects of psychedelics, including their impact on those struggling with cancer, depression or addiction. At the end of 2021, he discovered he had incurable stage 4 Colon Cancer. This conversation explores the relationship between meditation and psychedelics, and how they both can serve profound spiritual awakening and deep inner freedom in the face of mortality.

Information about the endowment fund: The Roland R. Griffiths, Ph.D. Professorship Fund in Psychedelic Research on Secular Spirituality and Well-Being.

I'm not a psychedelic researcher, but I have taken psychedelics, and I recently wrote "Strange trip: Psychedelics and confronting the fear of death:" https://jakeseliger.com/2023/09/25/strange-trip-psychedelics..., which covers similar themes.
Your blog is deeply moving, thank you for posting the link. When my time comes, I hope I accept it with the equanimity and grace you display.
Thank you and you're welcome, too!
A beautiful read, thank you for sharing. May you and your partner be well.
Thank you and you're welcome, too!
Great article. Thinking of you and your family.
I got to this late but thank you for sharing Jake, a beautiful read. Here's to hoping on the extraordinarily unlikeliness you'll still be with us in your 50s.
I wish there was more support to not just decriminalize but legalize psychedelics broadly. I know there are plenty of ongoing clinical trials, but the collection of Psilocybin, LSD, Mescaline, Ibogaine is genuinely a treasure chest and probably the best thing that has happened to medicine in a long time, if not ever.

Edit: i highly recommend watching Michael Pollan's "How to change your mind" (Netflix documentary). https://www.youtube.com/watch?v=X8LRb4jfZ9g

I’m not going to be that guy, because I don’t read nearly enough to begin with, but I read the book and… it was amazing. I have a deep appreciation for the psychedelic experience and reading his trip reports brought me, a 30 year old man, to tears.
What do psychedelics achieve here that ordinary meditation as in e.g. vipassana does not? They seem like a pointless shortcut, and potentially a problematic one. If the hallucinatory dynamic is specifically what you care about, that's also typical of perfectly ordinary experiences such as dreaming, or even just drifting in and out of sleep. What "treasure" are we gaining by dosing the brain with chemicals, that we couldn't otherwise?
This is very similar to "what do antidepressant medications achieve that regular diet and exercise do not? "

Assuming equal efficacy is possible in the first place, and assuming every human is even capable of reaching those levels, there are people who can't spend the sometimes years it takes to practice meditation to a point where they can achieve psychidelic efficacy.

Why not have both available and you can do you?

An equally valid and troubling question, doesn't really make your point.
The argument here is that psychedelics are more than "chemicals" and comparing them to drifting in and out of sleep is not a real comparison. Can't argue against them sometimes being problematic though, of course, but the argument here isn't acknowledging the real psychedelic experience. If curious, check out some reports on https://www.youtube.com/@Vivec
What I compared to drifting in and out of sleep was merely one effect of psychedelics that people tend to be curious about, namely hallucination. Moreover one can very much approach these dreamlike states with a meditation-like, non-judgmental, non self-centered mental posture, and this is going to make their effects even clearer.
Yes. As captured by the Big Lez Show:

> Donny: Panaeolus cyanescens, psychadellic.

> Lez: What do they do to ya?

> Sassy: Take you on a journey of self-discovery, you find out who you really are, this and that.

> Donny: Either that or you trip out for four or six hours. But in our current situation this will be really good for us, gunna heighten our senses so we'll be way more in tune with our surroundings.

> Lez: These heighten senses?

> Donny: They heighten senses you didn't even know you had.

> Lez: Have we got more than five?

> Donny: So many.

> Lez: How do I turn them on?

> Sassy: Meditate.

> Donny: Yeah meditation's probably the best way. Or, trip out on some psychedelic mushrooms.

https://www.youtube.com/watch?v=HPeSVlk6E70

I think the transcendent experience has a lot to do with it.
I love meditation and practice daily, but not everyone can do 1 hour a day (Goenka recommends two) and one ten day retreat a year.

If one or two guided trips can transform someone's relationship to death, that's hugely valuable.

(comment deleted)
> What do psychedelics achieve here that ordinary meditation as in e.g. vipassana does not?

I actually don't think it's worth comparing the two. They achieve a similar end goal depending on your intentionality but I don't think it's fruitful to say one is better than the other.

> They seem like a pointless shortcut, and potentially a problematic one.

Psychedelics certainly have a higher ability to be abused. People need to be educated on looking at their family mental health history, they need an informed trip sitter, and they need to be well informed on what the experience will entail.

On the other hand, how many guru cults that incorporate meditation as a form of psychological warfare and isolation have we witnessed in our lifetimes? The people who are casually allowed to walk around and profess themselves as prophets or gurus is highly adjacent to the consequences of ill-informed ego death and return in the psychedelic space.

> If the hallucinatory dynamic is specifically what you care about, that's also typical of perfectly ordinary experiences such as dreaming, or even just drifting in and out of sleep

Psilocybin, LSD, and DMT are nothing like dreaming. They're very vivid experiences. They can rip you out of your rooting in this reality which is why, imo, they're not good to do unless you have an informed trip sitter who can ensure your mental, emotional, and physical safety. That's what also makes them powerful teachers in the way of perspective; imo, it's not that you're "unlocking secrets to the universe" during a trip, moreso you've been granted a perspective outside of your sense of self that is difficult to achieve otherwise. Depending on the dose it could also be total dissolution of the ego. These things wear off, of course, but someone who can help you do a "soft landing" in the case where you run into some trauma makes a huge difference. The things you process afterward are where "the work" is done.

> What "treasure" are we gaining by dosing the brain with chemicals, that we couldn't otherwise?

You could meditate until your ego dies and likely achieve many of the same machinations from what I've read from peoples testimonies. Again, the work isn't done during meditation, it's how you decompose your experience and incorporate it into your life later. Psychedelics are the same, just a different mechanism that you cannot choose to say "I'm done" halfway through.

Psychdelics can and do kill meaningful amount of people, almost exclusively due to injuries while under their affects.

147 psychedelic deaths over three years - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1523208/

I'll have to find a youtube video but there's a good one with one of the psychdelic guru's describing a trip where had mis-dosed (he didn't realize the mushrooms he was consuming were significantly stronger than anticipated) and he ended up stuck in a "loop" of not being able to start his car.. for three or four hours. His exprience was distressing but not much of an injury, but he then delves into a story about how a similar loop resulted in one of his friends dying from repeatedly falling into cement.

How did the guy end up with 2 different neophyte people they were instructing in dangerous situations and sharing that. Let's not mince word, if the first had started the carit would be a dangerous situation. In college with alcohol wed stick a sober watcher over the pre-frosh who decided to drink the first time away from home.

Having just one go slightly sideways would make me really cautious. I was because freshman year I found some random pre-frosh who had hidden in a closet cause they thought they'd be in trouble (they were not, wet campus) who needed help.

If 147 in 3 years is "a meaningful amount of people" then we're gonna need to ban a lot of other stuff to stay consistent.
Why was he trying to start his car? I'm glad he couldn't figure it out otherwise he could have killed someone. This is a personal responsibility thing.
The paper you linked does not say what you claim it says.

Instead, it appears to investigate psychoactive drug deaths not to do with overdose.

There appear to be no "traditional" psychedelics (serotonergic hallucinogens like LSD, psilocybin, etc) covered here _at all_ except perhaps one death categorized as a "hallucinogen", which is definitely a lot less than 100% of the 147 deaths investigated.

You misquoted the title, which is actually, "Fatal injuries while under the influence of psychoactive drugs". There was no psychedelic fatalities other than 1 MDMA & alcohol one. Those were all booze, and other drugs. I'm not saying there are none, it's just the death rate during psychedelic trips is a actually lower than for sober people. On average those drive less and are often in group settings, so it's more those substances don't alter the death rate and the safety is provided by the context of not driving as much as typical, and not working with machinery.
When you say legalize broadly i guess you mean allow doctors to prescribe it to their patients with proper protocols and not just allow anyone to buy it over the counter?
When I talk about legalising drugs, I mean being able to buy them with the same level of control as beer or cigarettes.
Because beer and cigarettes are both mind-altering drugs yet get a pass because of mostly-economic reasons.
Not economic, historical. It's purely because both were things before the puritan movement (which still greatly impacts society today) and people are already familiar with them. If alcohol were discovered today, there's no way in hell it would be legal
So of course they’re both very old staples in human culture, but I mean to say that any attempts to regulate them are/will be met with more economic resistance than cultural… like Anheiser-Busch (spelling definitely wrong) and Philip-Morris (now Altria I believe) would be a bigger obstacle than “the people.”
Do cigarettes have such a big mind-altering effect?
I can’t speak personally, but people often get from nicotine what they would also get from marijuana- both have a “high” that makes you feel “different”, and the withdrawal symptoms from nicotine are more like those of meth than marijuana (which as far as I know, has no withdrawal since it’s non-addictive).
I understand that people are very different because if I took mushrooms when I was terminally ill, I would have a trip so bad it would break my mind.
Did a previous trip lead you to this belief are you just speculating on what your experience would be like?
I’ve had one bad trip (not terrible) when I was expecting some bad news. I’m basing it off of that experience. I’ve had a dozen other good trips but I was always careful to make sure I was in a good headspace before doing it.
AFAIK, there are 3 key ingredients to the trip: the set (before), the setting (during) and integration (the after). This is not a DIY therapy, but needs to be under a therapist's supervision.
(comment deleted)
How is this different from escaping problems through drug use?
Psychedelics are so different from alcohol and narcotics, idk how to explain. Instead of being distracted or numbed from your problems, you may concentrate on them deeply and from new angles.

But delusions can occur too. Ymmv.

Is it fair to infer that you have a value judgment on escaping problems through drug use, and think it's wrong or bad?

If so, why?

Yes. Instead of escaping, let's solve the problem instead.
Why do you think the former precludes the latter?

This seems to be like if someone comes to a doctor with an arrow stuck through him, someone saying "don't give him any pain killers, that's bad. Just take the arrow out so the problem is solved."

You should obviously remove the arrow to correct the root cause, but you don't need to deny the patient pain killers in order to do so. Judging him morally or legally for wanting them doesn't make sense to me, short of claiming that an unprovable all powerful being who talks to man only through extremely unreliable and non reproducable channels has revealed to us that it's actually a sin.

For me it depends on context; Pain exists for a purpose (i.e don't put wait on a broken leg otherwise you could extend healing time or make things worse) but if technology allows us to mitigate the potential problems (i.e fixing the bone and apply a cast will allow you to walk but not add strain) getting ride of pain in the meantime is probably a net good.

If you have chronic pain of some sort and you use substances to mask that pain the root problem hasn't been addressed and still exists, you just won't be aware of it. If loosing awareness (which at its simplest is what painkillers do) of the ongoing problem is okey with you by all means take a substance to mask it, just don't be surprised when the original problem grows worse latter.

Im okey with people masking or not masking. It should be a personal choice free of judgement.

There are two guys and both are extremely depressed. One guy decides to seek out a therapist and has a meeting set for two weeks from now, the other guy decides to take MDMA/LSD/shrooms (or whatever) every day. He feels amazing and is living his best life every day. The first guy is super depressed day to day but maybe the therapy will help...

The next week they are on a plane together that crashes. Who made the better decision?

Alternatively they don't die and instead live decades more. The first guy got to the root of his issues and lived a very happy life while the second eventually burned out and fell into even deeper depression for his remaining years. Who made the better decision?

It is not fair for us to judge others on how they would like to treat their own bodies and minds. We don't know the totality of their path through life.

Your point is taken, but it's not quite apples-to-apples.

Therapy can be a deep healing process or a superficial fix, just as psychedelics like shrooms, LSD, or MDMA can be used daily by some (suggesting a shamanic lifestyle, in my opinion) or lead to profound insights in a single ayahuasca trip for others.

It's true we shouldn't judge what works for someone without knowing them well, and even then, we can only offer suggestions. But when comparing, we should ensure we're not misrepresenting the situation, whether intentionally or not.

Totally. Yeah the comparison was extreme and not meant to equate things.

>"It's true we shouldn't judge what works for someone without knowing them well, and even then, we can only offer suggestions."

Very well said. I have had great success with psychedelics and other mind-altering substances but doesn't mean the next person will. I have yet to reap a great benefit from therapy but perhaps I just haven't found the right therapist either. To each their own.

> decides to take MDMA/LSD/shrooms (or whatever) every day. He feels amazing and is living his best life every day

Gonna go out on a limb here and guess that you've never taken LSD or shrooms... personally, taking them every day sounds nightmarishly exhausing (can't speak to MDMA).

In my experience, these drugs don't mask your problems, they surface/amplify them.

I have taken LSD and Shrooms countless times. I take MDMA multiple times a month as well. I guess the point though, for that example, was more along the lines of: take whatever substance floats your boat as much as you desire to remain in a happy state.

>"In my experience, these drugs don't mask your problems, they surface/amplify them."

MDMA will defiantly mask your problems. As will heroin, GBH, and a number of others. But yeah LSD/shrooms not so much.

Hey, maybe a little off topic but if you're still taking MDMA multiple times a month i would strongly suggest you should stop. It's known to be neurotoxin, especially in large doses, especially especially when done frequently, frequently being more than once in about 3 months. It doesn't matter what you're supplementing, effective doses of MDMA done every week or two will be catastrophic to the long term health of your serotonin system and cause chronic health issues that will take years and years to resolve, if they ever do.

I don't know you're situation, dose, knowledge, safety, etc. But in the off chance you're one of the many people destroying their future minds with this stuff, i have to say something. Google MDMA Supplementation Guide Reddit to find the best ways to reduce toxicity if you intend on continuing.

> In my experience, these drugs don't mask your problems, they surface/amplify them.

I agree, and therein lies the promise of these drugs in therapy. PTSD survivors engaging in MDMA-assisted therapy can finally surface and talk about their problems without the pain they usually feel just remembering.

How do you solve stage 4 terminal cancer?
My parent was diagnosed with stage 4. We tried to help and ultimately we all accepted death was near.
(comment deleted)
The problem to be solved in this case is unnecessary distress and pain about one's inevitable death.
And how do you solve that
One common solution is the hospice system. There's no silver bullet for any of this and it's a bit irksome see so many comments treating this like a "5 whys" exercise
I can tell you from first hand experience that while the hospice system is certainly better than nothing and has extremely helpful and useful aspects, it's also extremely expensive where i live and the only "spiritual" assistance available is through one specific church, as far as i was aware. Sure, she had a moderately comfy bed and assistants that came to drain her bags and talk but she was still terrified and constantly drugged up to keep from freaking out. Any tool that has even a chance of helping retain sanity and humanity in such a trial is worth researching and communicating. These psychedelic drugs provide a service that simply cannot be achieved with any hospice system, anywhere in the world, ever. To actively advocate against the dying beings allowed to feel peace is inhuman, incomprehensible, and if i weren't certain it was pure naivety, evil.

Psychedelics bring peace to the dying. What harm is that? That's what you're arguing against

And what is hospice but pumping someone full of morphine and ativan until they die?
The problem here is acceptance of one’s mortality. What solution do you propose?
Accept it fully.
Quite. How do you propose to do that?

And more importantly, how do you propose people who struggle to do this reach that acceptance?

The article talks about that and it seems the patient did accept the mortality fully:

> It wasn't that he was filled with spiritual language like, "God's gonna save me." No, it was an acceptance for his condition and a reassurance to the people he loved most, that everything was OK, everything was as it should be, and they felt uplifted by that.

It seems you're nearing the message. How does one accept that fully? What do we do in the face of struggles with what may be the greatest struggle a human being ever faces? Could there be some technique that could help? What would that technique look like? Could it include the ingestion of a substance? If ingesting said substance along with guided meditation was vastly superior to all other techniques of death acceptance, would that be avoiding the problem with drugs?

I think what you're not understanding is that taking the drug is the death acceptance technique. It is the thing that allows these people to quickly transition into peace. Do you have a better way? Could you please share that so all of our dying family members could finally have the simple solution you seem to be aware of?

The drug is just exposing these subjects to the experience of living fully in the present moment. This is not something that can be done as "one weird trick", it requires true spiritual maturation-- and yet, people who haven't learned how to do this are literally dying every single day, whether they realize this or not. Whatever time is past for them, is in Death's hands already. They can choose to dwell on this, or just not bother and live life to the fullest as best they can.
We are lucky enough to have two tools at our disposal:

1. Cultivating the spirit. This is slow and has a high abandonment rate, but it is second-to-none in terms of living a fulfilling life. It is worth pursuing, but is unfortunately ill-suited for rescuing people who are in the midst of a mental-health emergency. It should be thought of as "prevention".

2. Cultivating psychoactive substances. This is riskier than the first option, but it has two main advantages: (1) with some precautions, it is immensely helpful in connecting people with their spiritual lives and (2) in an emergency, it is reliably effective. This is on par with the discovery of antibiotics, in terms of medical significance. It should be thought of as "intervention".

Why anyone would willingly renounce the use of either? On what principle? This is obscurantism.

That's ideal, but some people don't have the resources to do that.
Because it can be about facing the problem, with assistance of an altered state opened by the psychedelic. They are tools in the right context.

(Disclaimer, working at ayahuasca retreat centers for the last 3 years so maybe biased as to what that context actually is :))

Because the kind of drug use you're thinking of means addiction to a substance (one that typically numbs you or makes you feel unnaturally happy). Here he's discussing about people improving their condition after a single dose.
His best example of a patient outcome is "patient came to believe in a Higher Power and felt at peace".

Why are we being so credulous?

You should not be relying on an interview for evidence anyway. I am no expert and I have no opinion one way or another. But you shouldn't have preconceived opinions either. Look for scientific literature if you're interested.
IMHO, it's perfectly fine, positive even to escape one's problems with drug use. You just can't do it every day.
If one could do you think that would be a problem?
I guess depends on the drug and the problem.

Daily use of lots of substances, e.g. alcohol, isn't necessarily a bad thing in itself (though it really can be), but if it's to escape a problem then there's a serious risk there. As the above suggested, the problem also remains unresolved.

So yeah, I don't think a person self-medicating on a daily basis is always problematic, but it's never worked out well for me, and it's not something I'd advise.

My original point was really that getting out of one's head once in a while can give a fresh perspective on a problem.

Depends on the drug.

Caffeine? Probably the most used and least worst, could still cause sleep disruptions.

Weed? Could be a problem. It's very easy to get mentally addicted to it and turn you into a bowl of mush, but if you're using it in medical doses I imagine it's less so.

Microdosing LSD? Depends from person to person. I think using it too often isn't good for the heart.

Alcohol? Absolutely a problem, even if the worst side effects take years to manifest.

Our bodies have the enzymes to process alcohol (as opposed to similar chemicals like isopropyl alcohol) since animals have been ingesting fermented foods since the beginning of time.

These rhetorical attacks on Alcohol in an attempt to normalize the use of other chemicals without a similar biological history is asinine.

Our bodies process every drug you put in it. What is your point?
It's not rhetorical. Alcohol is empirically more harmful than all of the other drugs mentioned (in large part because of how said enzymes process it). How long it's been around has nothing to do with it.
Physical damage is not the only kind of damage.

I'd be more concerned with psychological damage.

People who drink alcohol typically don't go around telling people they communed with entities from another dimension and they realized that all of existence is one harmonious unity.

Or whatever.

Is that so bad by comparison, though? Assuming a "serious effects" dosage (i.e. not a microdose and not a single whisky shot) I'd rather spend a while dealing with machine elves or considering the universe a glorious and meaningful harmony than being miserably dizzy and puking in a bucket. I'm not anti-alcohol, but as drugs go it's not exactly the most entertaining experience on offer.
Confronting problems with medicinal assistance.

Intention makes a difference.

Most folks associate taking psychedelics and hanging out in a living room, out in nature, being at a club, festival or warehouse. The difference here is that the dugs are being used in a directed mental health setting with process and procedure. This has roots going back to Native American spiritual and communal experiences like the ayahuscaeros of today.

Joe Rogan's old content postulates that religion as we know it today was formed from psychedelic experiences. For example, the bush that burned in front of Moses was acacia and widely known in the levant to have psychedelic properties

https://www.youtube.com/watch?v=fwV8_Oc0EuY

Hate that Joe Rogan co-opted Terrence McKenna's huge body of work. And badly, at that.
That’s a strange way to explain away Moses’ encounter with God (what is written), seeing as according to the text it occurred many times without the burning bush present. See Exodus 33 on the tent of meeting.

Reading in psychedelics into the text is eisegesis rather than exegesis (reading in the interpreters bias into the text rather than discerning the original author’s intent).

Simple answer, It's not.

Approaching a horrible situation with calm acceptance and resignation is pathological insanity.

Don't let anyone tell you different.

Let me fix it for you: Approaching a horrible situation with calm acceptance where you can't do anything is pathological sanity. Learn about dichotomy of control.
Calm and acceptance are two different things.

It's self defeating to judge a situation as "I can't do anything about it I should calmly accept it."

You can rarely if ever know with 100% certainty that you "can't do anything". And even then there are usually things you can do (or could have done).

Your emotional state with respect to a external situation is irrelevant, be stoic by all means.

But thats not what we're talking about here. We're talking about people using mind altering substances to alter their mind rather than face the situation and do what they can.

Simple answer, It's not.

Approaching a horrible situation with calm acceptance and resignation is pathological insanity.

Don't let anyone tell you different. Especially not someone whose mind has been impaired by drugs.

Drugs alter your subjective experience, how can you then understand whether your experience is true, and you are not simply operating with a defective brain.

In these cases it is the latter. If it was natural to feel a certain way, and that feeling was advantageous to the survival of our species, then your brain would already be that way. Tamper with it at your own peril.

For my part, I will wish to maintain my knowledge of reality and make my last minutes count without any false sense of acceptance of the utter evil that is death.

Gosh, Poe's law is strong here. I was certain you were serious until that last sentence. But some people really do think like that so... are you being sarcastic?
It is a very unpopular opinion, I am well aware.

Mind-altering drugs are bad. If you have used them, you may have damaged your mind permanently.

You wouldn't even know. And you'd even go far as to tell me that it made you smarter/better/more enlightened in some way.

Objectively though, it didn't.

"This life is only a prelude to eternity." - Seneca

You can mostly avoid upsetting people with the God language by talking about love of truth instead.

Can't we say, with nearly as much accuracy, that this life is an epilogue to eternity?
I don’t think so. Eternity, by definition, never ends, so this life couldn’t come after the end.
Mmm. That presupposes infinite linear time. By most accounts, "this life" bookends about 13.7 billion years of linear time, but how do we understand the state of things before that?

How could we understand the state of things once the heat death of the universe is a distant cosmic memory, and entropy no longer provides an "arrow of time"?

Everything we know about time is total order, but partial order is also possible.
it's a stop along the way from infinity to forever

stretch your legs :)

Either case sounds like some fancy mental gymnastics to feel good about uncertainty. Much better to embrace it and admit, "I don't know."
Tried looking for a source to this quote by Seneca (the Younger, I assume) and couldn't find one anywhere. Do you have a source ganzuul? The WikiQuote entry is quite expansive and thorough, yet I was unable to <ctrl + f> your provided quotation — even in the "Discussion" tab. https://en.wikiquote.org/wiki/Seneca_the_Younger
Griffiths was the driving force behind mainstream acceptance of psychedelic medicine with his work at Johns Hopkins. He showed that psilocybin was not only effective but was the most effective treatment for terminal psychiatric care and addiction, and he did it all within the mode of academic medical research. I hope his death was painless. A great scientist deserves no less.
it was his character in combo with the delics. this kind of treatment can only be taught if aspiring teacher/psych/shrink is super-rational and NOT at all if said person is rational (=pseudo-rational)
(comment deleted)
This is not mentioned in the article, but upon learning about his prognosis Griffith worked on establishing an endowment to support the continued research on psychedelics and "secular spirituality and well-being".

I recommend watching Griffith's video message [0] where he talks about the research and reflects on his condition. I also recommend the conversation with Sam Harris that someone else shared in a comment.

[0]: https://griffithsfund.org/vision/