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yawpitch
“[I]nduces cellular senescence”, to those not steeped in the hip lingo, means “makes cells older”.
jijijijij
I think this is somewhat incorrect. 'Senescence' is a particular state in cells, where they stopped cell division due to dysfunction, but are not broken enough to induce apoptosis - programmed cell death. Accumulating senescent cells in turn is associated with age related disease.
pvaldes
And here implicitly, "make several organs age faster" so... very bad thing.
perilunar
But also note: "Our study showed that an IKD [intermittent ketogenic diet] can prevent the accumulation of senescent cells induced by sustained KD [ketogenic diet] ... suggesting that an IKD may be more beneficial than a long-term continuous KD"
desmond373
This lines up well with the idea that few carb were eaten during winters in northern climates. I wonder if this is actually an evolutionary gene.

Personally when lossing weight I've mainly done 2-3 month stints of keto followed by calorie counting. Its worked well when ive stuck to it.