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Such an incompatibility, they note, would have likely led to hemolytic disease in offspring if a Homo sapiens or Denisova male were to mate with a Neanderthal female—a result that would have led to a host of health problems that would have prevented the offspring from maturing and reproducing. If such a practice became widespread, they suggest, it could have been a contributing factor to the demise of Neanderthals.

Isn’t that a huge IF?