Hackable AlphaFold 3 without Docker or MSAs (github.com)

his is a lightweight, hackable way to run AlphaFold 3 that lets you experiment without the massive MSA databases or Docker overhead. Perfect for tinkering on your laptop or single GPU server - just install, drop in your sequences, and start predicting. No 100GB downloads, no container bloat, just pure structure prediction you can play with in a Jupyter notebook.