23 comments

[ 4.3 ms ] story [ 107 ms ] thread
This is why you need to include a good vitamin C serum in your daily skincare routine.
"I always use an after-shave lotion with little or no alcohol because alcohol dries your face out and makes you look older. Then moisturizer, then an anti-aging eye balm, followed by a final moisturizing "protective" lotion..."

Bateman stares into the mirror. The masque has dried, giving his face a strange distorted look as if it has been wrapped in plastic. He begins slowly peeling the gel masque off his face.

Which daily skincare you recommend to use?
I get all my skincare advice from hackernews.
A, B, C, D, E and water.

A is a light retinol. B is niacinamide. C is C. D you should be making from sunlight (or getting from supplements). E is E. Water is moisturiser.

Pretty much all evidence-based skincare comes down to providing these vitamins (plus water) to your skin.

So possible treatment for age related thinning of the skin.
Oh lord, not another "wellness hack". And here comes the people giving themselves kidney stones and spinal cord problems to be featured on Chubbyemu.

https://youtu.be/oeyt2zVqCG8

(comment deleted)
In cell cultures. So nothing about topical, or digestive pathways. Just, expose cells to vitamin c rich medium.

How would topical application work, and what kind of homeostasis effect, from ingestion.

If you are low on vitamin c in your diet, sure. If not, you may not get much benefit from having more.

Topical vitamin C (L-ascorbic acid) at concentrations of 10-20% with pH <3.5 can penetrate the stratum corneum, though stability and formulation significantly impact bioavailability.
Everybody is low on C in diet. It's thermolabile, and there is glucose competition for GLUT transporters.

IMO, everybody should take at least 2g daily in a couple of doses, particularly smokers.

> IMO, everybody should take at least 2g daily in a couple of doses

I strongly caution against this kind of blanket recommendation. For most people, taking such a high dose without medical guidance is unwise. Unless a healthcare professional has specifically advised it, this level of supplementation goes well beyond established guidelines.

There is substantial research highlighting potential risks, including kidney damage, associated with high-dose vitamin C intake (as referenced elsewhere in this thread).

Anyone considering this should thoroughly research the risks and consult a qualified medical professional before proceeding.

Maybe plasters with ascorbin acid in it? That would be the first thing that comes to mind. Or maybe plaster spray where it's mixed with the typical protein foam?
As a vaguely related aside, my skin is typically better when I have a decent vitamin c intake. Essentially all I do is have a orange or two every night. Nothing too extreme.

This is VERY anecdotal!

This just found a potential mechanism, right? Because we did know that, AFAIK. A doctor recommended me vitamin C for faster healing of minor lesions about a decade ago.
So true. I have been vitamin-C deficient the past 20 years and my skin has definitely degraded.
With conflicting evidence that vitamin C may promote tumour growth, how much study has been done as to whether this might exacerbate skin cancer?
Pauling spins furiously in his grave in approval.
Could be why so many suggested home skin remedy moisturisers contain lemon juice.
Vitamin C supplements and cancer risk is an active area of research. Unless there is a genuine deficiency, I would stay away from supplements just to look pretty until there is more clarity.
Vitamin C/ascorbic acid/swimming pool cleener is interesting stuff, but it is not generaly benificient as a suppliment for healthy people. I will(very) occasionaly chew up a gram, or throw a spoon full into a summer drink concoction, but I also know someone who got a tounge blister from copying me chewing up a vitC pill, someone I knew well, who had such different respinses to things that we started to experiment lightly,they also had a variant form of collegen in all of there conective tissue, which made them vastly more flexible than most people......which(oddly)relates to the titles subject matter