I used to think I was "awake" because I became intensely aware of my mortality in my early 20s. But actually I feel like that's the norm, these days.
Gen Z seem to take "YOLO" seriously from a young age. Nobody is planning for anything beyond their own lifetimes. Some people still can't resist their biological imperative and have kids, but they're all basically YOLOing their lifestyles and their actions, if not their words, are saying "not my problem, you'll figure it out when I'm gone".
So, yeah, be aware you won't be here forever, but what we need is for people to leave the damn place in a better state than they found it, or at least not worse.
They gave the mice 15mg, which is about a low-medium dose for a human. But humans weigh about 2000 times what mice do, so the effects were observed at about 2k times a reasonable dose.
1) Those mice must have been completely out of it.
2) This probably isn’t helpful to humans unless given under sedation. Or maybe that extreme a dose is equivalent to sedation, I’m not sure anyone has taken 30 _grams_ of psilocybin to tell us?
Across species dose adjustment is based on surface area rather than mass.
Mass is proportional to volume. Volume increases super-linearly with respect to area. Therefore area increases sub-linearly compared to volume. Therefore dose increases sub-linearly with respect to volume. Therefore does increases sub-linearly with respect to mass.
> 1) ya, at that dose those mice, while unable to parse the Beautiful Mind style mathematical symbols they saw floating by, still understood the true meaning of them in ways the human mind can't begin to imagine
It may be a secondary effect - that the extension of life from reduction of cellular damage was due to the mice being less stressed out mentally after being stoned.
Some comments here refer to a "tolerance" aspect of psilocybin. It might be more clearly termed 'refractory period'. Stan Grof from his clinical work would time LSD sessions no closer together than 1 week and that short period was unusual, usually with OCD patients. I have a friend with moderate OCD, has dosed several times on psychedelics and never gotten an effect.
16 comments
[ 4.4 ms ] story [ 37.7 ms ] threadPsilocybin treatment extends cellular lifespan, improves survival of aged mice (nature.com)
43 points | 1 day ago | 10 comments https://news.ycombinator.com/item?id=44527358
Psilocybin for major depression granted Breakthrough Therapy by FDA (newatlas.com)
1240 points | 6 years ago | 471 comments https://news.ycombinator.com/item?id=21638290
What happens when clergy take psilocybin (nautil.us)
353 points | 25 days ago | 566 comments https://news.ycombinator.com/item?id=44293610
Gen Z seem to take "YOLO" seriously from a young age. Nobody is planning for anything beyond their own lifetimes. Some people still can't resist their biological imperative and have kids, but they're all basically YOLOing their lifestyles and their actions, if not their words, are saying "not my problem, you'll figure it out when I'm gone".
So, yeah, be aware you won't be here forever, but what we need is for people to leave the damn place in a better state than they found it, or at least not worse.
1) Those mice must have been completely out of it. 2) This probably isn’t helpful to humans unless given under sedation. Or maybe that extreme a dose is equivalent to sedation, I’m not sure anyone has taken 30 _grams_ of psilocybin to tell us?
Mass is proportional to volume. Volume increases super-linearly with respect to area. Therefore area increases sub-linearly compared to volume. Therefore dose increases sub-linearly with respect to volume. Therefore does increases sub-linearly with respect to mass.
As long as one of them can code I’ll be fine
Bonus if the other one can do marketing