> What UK Biobank is revealing, scan by scan and layer by layer, is that disease doesn’t arrive out of nowhere. It accumulates quietly, shaped by genes, environment, and habits.
I think that is already known for a while. It's called functional reserve, and was a big topic in HIV patients (and then again for SARS-CoV-2).
Like people with higher cognitive capabilities will be protected by those a bit longer before onset of HIV-associated neurocognitive disorder (or even dementia).
Same for kidneys: They have a functional reserve that you are born with gets used up during life, until it is gone. Acute kidney disease treatment is aimed at preserving whatever little function is left.
To me, this is the strongest argument for a centralised health system, such as the UK NHS.
When you have one organisation responsible for health as a whole rather than just treatment, you can make better decisions. The usual example I give is that it's cheaper to give out the contraceptive pill than deal with pregnancies, but the same thinking applies to broader disease and health.
It’s interesting they make no mention of trying to understand the body’s ability to self-defend and self-heal. That is, it’s possible to get X (e.g., cancer) and the immune system wins the fight (before it’s even detected).
In theory it’s possible the best early treatment is no treatment at all; that there might be such a thing as too-early detection.
And yet not a single doctor in the United States will permit you to care about early signals, preventative medicine, or routine deep dive bloodwork, in order to stave off those diseases. Anyone who's on top of this is paying fully out of pocket for individual tests, screenings, medicines. Manageable for some, unattainable for most.
Huh? Plenty of doctors out there cater to the "worried well" and will order any blood work you want or spend a lot of time with you on preventive care. But of course most health insurance plans won't pay for that. In most cases it's a total waste and doesn't significantly improve patient outcomes.
My ex girlfriend was a doctor and we talked about this once. The gist of it that I got was that excessive early tests have a lot of risk factors that come along with them, because tests themselves being harmful (CT scans cause something like 5% of all cancers), and because false positives lead to unnecessary treatments, surgeries, medications, etc which can cause real harm. Basically, if the expected harm from the proactive testing is greater than the expected harm it would mitigate, you don't do it.
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[ 0.16 ms ] story [ 70.2 ms ] threadthere should be more like it. (thanks for the archive link btw!)
I think that is already known for a while. It's called functional reserve, and was a big topic in HIV patients (and then again for SARS-CoV-2).
Like people with higher cognitive capabilities will be protected by those a bit longer before onset of HIV-associated neurocognitive disorder (or even dementia).
Same for kidneys: They have a functional reserve that you are born with gets used up during life, until it is gone. Acute kidney disease treatment is aimed at preserving whatever little function is left.
When you have one organisation responsible for health as a whole rather than just treatment, you can make better decisions. The usual example I give is that it's cheaper to give out the contraceptive pill than deal with pregnancies, but the same thinking applies to broader disease and health.
In theory it’s possible the best early treatment is no treatment at all; that there might be such a thing as too-early detection.