The German Wikipedia article says it appears naturally in cheese, funghi, plums, strawberries and pistachios. So maybe the lab experiment might be a bit artifial, or the dose much higher than from normal consumption if the above?
This is a study done on cell cultures. It should NOT be used to influence behaviors regarding human health. The article linked makes a lot of leaps not supported by the study itself.
To the reader, I strongly urge not listening to some rando on the internet (in opposition to the scientists) who asks you to dismiss a study, because the risk-reward calculus here is strongly in favor of not taking the unnecessary risk of brain damage.
Seeing as this is an in vitro study, they fall back on a specific human study (Witkowski et al., 2023) for many of the human effect claims. However the referenced study has a few issues:
- All study subjects had a "high prevalence of CVD [cardiovascular disease] and risk factor burden"
- Erythritol occurs naturally in the body and and this was not accounted for
- The study subjects were already suffering from cardiovascular disease and were likely to be consuming more artificial sweeteners than a general population, but this was not recognized or accounted for
- Erythritol's presence after a cardiovascular incident could be from consumption or from natural production but only baseline was measured despite data showing dramatic fluctuations after consumption
Another one of the studies cited for evidence of human claims (Khafagy et al., 2024) directly contradicts them. It stated said "we did not find supportive evidence from MR that erythritol increases cardiometabolic disease".
There are two more human studies referenced but I didn't read them.
> FWIU, beta-cyclodextrin is already FDA approved, and injection of betacyclodextrin reversed arterio/atherosclerosis; possibly because our arteries are caked with sugar alcohol and beta-cyclodextrin absorbs alcohol
I have never taken beta cyclodextrin for any indication. I thought I would relay the study and that it's already approved for human use.
FWIU when the sugar industry maligned fat in the US in the TODO, food manufacturers replaced fat in "reduced fat" foods with fake sugar substitutes which each have harms, high fructose corn syrup, or molasses.
What percentage of cardiovascular "plaque" is sugar alcohol and thus apparently treatable with β or α cyclodextrin, in controls and patients with conditions like Arteriosclerosis and Atherosclerosis?
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[ 3.6 ms ] story [ 38.1 ms ] threadWould the whole drink amount really all be given to those cells?
The German Wikipedia article says it appears naturally in cheese, funghi, plums, strawberries and pistachios. So maybe the lab experiment might be a bit artifial, or the dose much higher than from normal consumption if the above?
Dosage is still a thing.
Link to actual study: https://journals.physiology.org/doi/full/10.1152/japplphysio...
- All study subjects had a "high prevalence of CVD [cardiovascular disease] and risk factor burden"
- Erythritol occurs naturally in the body and and this was not accounted for
- The study subjects were already suffering from cardiovascular disease and were likely to be consuming more artificial sweeteners than a general population, but this was not recognized or accounted for
- Erythritol's presence after a cardiovascular incident could be from consumption or from natural production but only baseline was measured despite data showing dramatic fluctuations after consumption
Another one of the studies cited for evidence of human claims (Khafagy et al., 2024) directly contradicts them. It stated said "we did not find supportive evidence from MR that erythritol increases cardiometabolic disease".
There are two more human studies referenced but I didn't read them.
Since I have to watch out for it, I've noticed it's becoming more and more common as a sweetener.
From https://news.ycombinator.com/item?id=43299867 :
>> "Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming" (2016) https://www.science.org/doi/10.1126/scitranslmed.aad6100
>> "Powdered Booze Could Fix Your Clogged Arteries" (2016) https://www.popsci.com/compound-in-powdered-alcohol-can-also...
> FWIU, beta-cyclodextrin is already FDA approved, and injection of betacyclodextrin reversed arterio/atherosclerosis; possibly because our arteries are caked with sugar alcohol and beta-cyclodextrin absorbs alcohol
Have you been taking beta-cyclodextrin for a while? In what dose?
FWIU when the sugar industry maligned fat in the US in the TODO, food manufacturers replaced fat in "reduced fat" foods with fake sugar substitutes which each have harms, high fructose corn syrup, or molasses.
What percentage of cardiovascular "plaque" is sugar alcohol and thus apparently treatable with β or α cyclodextrin, in controls and patients with conditions like Arteriosclerosis and Atherosclerosis?
https://www.youtube.com/watch?v=RuOvn4UqznU