Mine started late-thirties. Stomach doesn't handle spices as it used to. Any bravery at dinner time means poor sleep and tiredness for a day or two. Bumps/strained things take days to stop hurting.
It's very likely that aging is driven by some kind of scheduled gene program. It makes perfect sense to phase out individuals from a group-level selection point of view.
I felt incredibly old from ~36 - 42.
Then I started seriously working out, took control of my diet (it had very much always controlled me) and started aggressively pursuing a "better living through chemistry" approach to life.
I feel 25 years younger now. My BP and cholesterol are under control and I roll out of bed actually feeling rested (probably due to not snoring anymore).
There was another recent study that made the front page of HN (would have to search to find it) that found two "peaks" of aging, at 44 and 60. As someone in my late 40s, I certainly identified with that.
I was in fairly good shape and feel like, despite some grays and some crows feet, my body was relatively the same from my early 20s to my early 40s. 44 really did hit me like a ton of bricks though - working out got considerably harder, and my face started to show more permanent signs of aging, like loss of facial fat and neck banding. Can't say I was thrilled to later discover I was "right on schedule".
I think this study adds to growing evidence that aging doesn’t progress linearly. There’s less evidence supporting a specific inflection point for aging. If aging is like any other biological process, it’s likely to vary a lot between individuals depending on genetic, lifestyle and environmental factors and within an individual between different tissues. Until we develop accurate measures of tissue aging, there’s much we can do other than live as well as we can and as hard as possible.
14 comments
[ 2.5 ms ] story [ 39.3 ms ] threadStudy: https://www.cell.com/cell/abstract/S0092-8674(25)00749-4
https://med.stanford.edu/news/all-news/2024/08/massive-biomo...
I feel 25 years younger now. My BP and cholesterol are under control and I roll out of bed actually feeling rested (probably due to not snoring anymore).
I was in fairly good shape and feel like, despite some grays and some crows feet, my body was relatively the same from my early 20s to my early 40s. 44 really did hit me like a ton of bricks though - working out got considerably harder, and my face started to show more permanent signs of aging, like loss of facial fat and neck banding. Can't say I was thrilled to later discover I was "right on schedule".
What is this BS?