This isn’t really surprising at all IMO, but it’s nice that it’s been confirmed.
> “The researchers believe semaglutide’s anti-aging properties stem from its effects on fat distribution and metabolic health. Excess fat around organs triggers the release of pro-aging molecules that alter DNA methylation in key aging-related genes. By reducing this harmful fat accumulation and preventing low-grade inflammation - both major drivers of epigenetic aging - semaglutide appears to create a more youthful biological environment.“
In other words, being medically obese ages your body quite a bit, its stresses out your body with inflammation, etc. Taking Ozempic helps people lose weight, which also reduces inflammation. This is sort of like saying we proved rain (usually) increases humidity lol. A very obvious finding.
The article even says “ Randy Seeley from the University of Michigan Medical SchoolView company profile expressed little surprise at the findings” :)
I've read [citation needed] that semaglutide has anti-inflammation effects even when there's no weight loss, i.e. there's another mechanism at play as well.
Any study which uses epigenetic clocks can be discarded. There is to my knowledge no test which produces reliably measurements which don't have big error bars. The only conclusion this study can really make is: Ozempic changes the 'thing' which the epigenetic clock test also measured.
This is specifically a study on people with HIV-associated lipohypertrophy, which is associated with accelerated aging. Not clear what this would mean for people generally.
I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.
I was one of them, and changed my mind. Ozempic seemed like too much of a wonder drug. Being conditioned that some things just seem too good to be true I avoided it for many years. But as the number of years passed and the amount of evidence of ill effects remained steady, the scale flipped and I got enough assurance that it's not just brilliant marketing or malicious evidence hiding. I guess that I would like to define myself as "cautiously optimistic" but in the back of my mind it seemed like there was something there that was not being revealed.
I've been taking it for a few months now and it really does seem like a wonder drug. All the benefits I needed without any noticeable drawbacks. It's weirdly good.
Be very cautious with these miracle drug headlines. There's a strong financial incentive to highlight only the good news.
My mother, a healthy and active 87-year-old, started taking Ozempic because she was overweight and her doctor was impressed by the drug’s supposed miracles. She ended up suffering from severe intestinal motility issues, went through a lot of pain, and had to be admitted to the ICU.
The long-term systemic effects of these drugs are still largely unknown.
I guess maybe I'm one of the few who consider "reversing 3.1 biological years" to be a personal insult. Something that polled well in a group of pre-kindergarteners. What happened, some statistical bloodwork metric was tortured to produce such a claim? A mouse population survived the lab a little longer?
In a recent podcast[0], Ben Bikman explained some of background and pitfalls of GLP-1 drugs. When the drugs were first prescribed, dosages were much smaller than the dosages now prescribed for weight loss. Microdosing might be a better and safer strategy.
The podcast is only 3 hours long! The GLP-1 discussion starts at 2:09:53.
It's not GLP-1's in particular, it's protective effects of manifold evolutionary adaptations to semi-regular caloric deficits. Cancer and CHD go way, way up with Westernized diets.
My bet is on the reduction in inflammation -- it's a notoriously beneficial positive side effect of GLP1 Receptor Agonists, along with the obvious reduction in weight or HbA1c.
Currently the only people experimenting with it are the underground gray market peptide enthusiasts (you can find them on reddit and elsewhere), but the results are quite intense.
[EDIT] Just to be clear, gray market Retatrutide is illegal, I'm not encouraging you to buy it or do even take GLP1s in general. The point is that we have a preview of anecdata from people (with obviously high risk tolerance) taking this drug.
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[ 2.3 ms ] story [ 96.5 ms ] thread> “The researchers believe semaglutide’s anti-aging properties stem from its effects on fat distribution and metabolic health. Excess fat around organs triggers the release of pro-aging molecules that alter DNA methylation in key aging-related genes. By reducing this harmful fat accumulation and preventing low-grade inflammation - both major drivers of epigenetic aging - semaglutide appears to create a more youthful biological environment.“
In other words, being medically obese ages your body quite a bit, its stresses out your body with inflammation, etc. Taking Ozempic helps people lose weight, which also reduces inflammation. This is sort of like saying we proved rain (usually) increases humidity lol. A very obvious finding.
The article even says “ Randy Seeley from the University of Michigan Medical SchoolView company profile expressed little surprise at the findings” :)
https://www.pnas.org/doi/abs/10.1073/pnas.2420092122
I've been taking it for a few months now and it really does seem like a wonder drug. All the benefits I needed without any noticeable drawbacks. It's weirdly good.
My mother, a healthy and active 87-year-old, started taking Ozempic because she was overweight and her doctor was impressed by the drug’s supposed miracles. She ended up suffering from severe intestinal motility issues, went through a lot of pain, and had to be admitted to the ICU.
The long-term systemic effects of these drugs are still largely unknown.
The podcast is only 3 hours long! The GLP-1 discussion starts at 2:09:53.
[0] https://www.foundmyfitness.com/episodes/ben-bikman
EDIT: ycopilotFYT version https://www.cofyt.app/search/dr-ben-bikman-how-to-reverse-in...
https://glp1.guide/content/semaglutide-vs-tirzepatide-clinic...
My bet is on the reduction in inflammation -- it's a notoriously beneficial positive side effect of GLP1 Receptor Agonists, along with the obvious reduction in weight or HbA1c.
https://glp1.guide/content/a-new-glp1-retatrutide/
Currently the only people experimenting with it are the underground gray market peptide enthusiasts (you can find them on reddit and elsewhere), but the results are quite intense.
[EDIT] Just to be clear, gray market Retatrutide is illegal, I'm not encouraging you to buy it or do even take GLP1s in general. The point is that we have a preview of anecdata from people (with obviously high risk tolerance) taking this drug.
You’re so smart!