From GPT-4 to GPT-5: Measuring progress through MedHELM [pdf] (fertrevino.com)
I recently worked on running a thorough healthcare eval on GPT-5. The results show a (slight) regression in GPT-5 performance compared to GPT-4 era models.
I found this to be an interesting finding. Here are the detailed results: https://www.fertrevino.com/docs/gpt5_medhelm.pdf
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[ 3.3 ms ] story [ 38.8 ms ] thread[1]https://crfm.stanford.edu/helm/medhelm/latest/#/leaderboard
eg - GPT-5 beats GPT-4 on factual recall + reasoning (HeadQA, Medbullets, MedCalc).
But then slips on structured queries (EHRSQL), fairness (RaceBias), evidence QA (PubMedQA).
Hallucination resistance better but only modestly.
Latency seems uneven (maybe more testing?) faster on long tasks, slower on short ones.
"in my experience [x model] one shots everything and [y model] stumbles and fumbles like a drunkard", for _any_ combination of X and Y.
I get the idea of sharing what's working and what's not, but at this point it's clear that there are more factors to using these with success and it's hard to replicate other people's successful workflows.
Are they really understanding, or putting out a stream of probabilities?
I'm guessing HeadQA, Medbullets, MedHallu, and perhaps PubMedQA? (Seems to me that "unsupported speculation" could be a good thing for a patient who has yet to receive a diagnosis...)
Maybe in practice it's better to look at RAG benchmarks, since a lot of AI tools will search online for information before giving you an answer anyways? (Memorization of info would matter less in that scenario)