The reasoning behind this is that birds have higher body temperature in our fever range.
They put mice infected with a flu virus modified to have the bird variant of a gene in an oven and the virus indeed didn't degrade as much compared to the unmodified control.
Maybe it'd then be a good idea to have labs secretly funded by a joint venture half-US, half-Chinese, in China, doing gain-of-function research on these?
And then maybe that if some shit hits the fan, it'd then be a great idea to ask someone neck and tie deep in that funding and in that research to act as the "expert" to tell us if we should put masks on or not once it leaks?
I'd imagine that in the event of a Bird Flu pandemic, a vaccine would be developed and dispatched quite quickly, unlike with COVID, where during the early days experts were saying it was possible we'd never get a vaccine.
Huh. I don’t know if I’m picking up what they’re putting down here, but it kind of sounds like suppressing fever e.g. with Tylenol would actually be bad for (normal) flu progression.
kind of sounds like suppressing fever e.g. with Tylenol would actually be bad for (normal) flu progression.
you're just the tip of the iceberg my friend - did you know "horse dewormer" ivermectin has long been given to humans - for decades - to treat parasitic infections?
I wonder if Tryptase affects Avian flu as well. Anyone know?
I'd also argue my partner and I got Avian flu one Xmas from eating free range eggs when there was an Avian flu pandemic up the road from them in Norfolk and the British Govt ordered culls.
Tryptase:
"A striking finding was decreased tryptase content in mast cells with copper overload, whereas copper starvation increased tryptase content." [1]
"Influenza A viruses are negative-stranded RNA viruses. Like many other enveloped viruses, they code for a surface glycoprotein that must be cleaved by cellular proteases for activation. HA, a major influenza surface glycoprotein, is translated as a single protein, HA0. For viral activation, HA0 (assembled as trimers) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity" [2]
I also wonder, by virtue of being a single strand of RNA, how long does it take for mutations to make the virus no longer viable in the environment it resides in?
In other words is a this a 3-4day process of replication and mutation which in effect kills itself off, rendering the need for immune system response and cough, cold, flu rememdies nothing more than containment effects?
I also wonder, by virtue of being a single strand of RNA, how long does it take for mutations to make the virus no longer viable in the environment it resides in?
Jul 13, 2021
Possible impact on hospitalisations from different R rate scenarios #TheDailyTelegraph
Mar 15, 2021
'Prof Harnden said annual Covid vaccinations could be necessary to keep on top of the virus in the years to come, much like the flu jab. "The virus mutates, [but it] probably doesn't mutate as much or as quickly the influenza virus, so it's very difficult to predict...' #Telegraph
16 comments
[ 3.4 ms ] story [ 30.9 ms ] threadhttps://news.sky.com/story/uk-prepares-five-million-vaccine-...
They put mice infected with a flu virus modified to have the bird variant of a gene in an oven and the virus indeed didn't degrade as much compared to the unmodified control.
And then maybe that if some shit hits the fan, it'd then be a great idea to ask someone neck and tie deep in that funding and in that research to act as the "expert" to tell us if we should put masks on or not once it leaks?
you're just the tip of the iceberg my friend - did you know "horse dewormer" ivermectin has long been given to humans - for decades - to treat parasitic infections?
I'd also argue my partner and I got Avian flu one Xmas from eating free range eggs when there was an Avian flu pandemic up the road from them in Norfolk and the British Govt ordered culls.
Tryptase:
"A striking finding was decreased tryptase content in mast cells with copper overload, whereas copper starvation increased tryptase content." [1]
[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC5728160/
"Influenza A viruses are negative-stranded RNA viruses. Like many other enveloped viruses, they code for a surface glycoprotein that must be cleaved by cellular proteases for activation. HA, a major influenza surface glycoprotein, is translated as a single protein, HA0. For viral activation, HA0 (assembled as trimers) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity" [2]
[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC33880/
I also wonder, by virtue of being a single strand of RNA, how long does it take for mutations to make the virus no longer viable in the environment it resides in?
In other words is a this a 3-4day process of replication and mutation which in effect kills itself off, rendering the need for immune system response and cough, cold, flu rememdies nothing more than containment effects?
"A striking finding was decreased tryptase content in mast cells with copper overload, whereas copper starvation increased tryptase content." [1]
Interesting copper-binding metalchaperone metal homeostasis project advertised at Durham. https://www.findaphd.com/phds/project/how-do-copper-binding-...
'The wrong metal in the wrong enzyme is toxic.'
I also wonder, by virtue of being a single strand of RNA, how long does it take for mutations to make the virus no longer viable in the environment it resides in?
Jul 13, 2021 Possible impact on hospitalisations from different R rate scenarios #TheDailyTelegraph