I got about a page in before finding out this is drivel. The final straw was "AI companies showed up and solved it in an afternoon". No faster way to show you don't know what you're talking about.
The secondary structure graphic is entirely wrong. It's full of bad chemical formulas, and I would assume is AI-generated.
I'm quite impressed by the amino acid overview graphic. I'm sure all images are AI-generated, and this one is something I didn't expect AI to be able to do yet. There are mistakes in there (e.g. Threenine instead of Threonine, charged amino groups for some amino acids), but it doesn't look immediately wrong. Though I haven't needed to know the chemical formular for all the amino acids in a long time, so there are probably more errors in there I didn't immediately notice. The angles and lengths of the bonds are not entirely consistent, but that also happens without AI sometimes if someone doesn't know the drawing tools well. The labels are probably the clearest indicator, because they are partly wrong and they are not consistent as they also include the non-side-chain parts sometimes, which doesn't make sense.
The biology part of the text looks somehwat reasonable overall, I didn't notice any completely outrageous statements at a quick glance. Though I don't like the "folding is reproducible" statement as that is a huge oversimplification. Proteins do misfold, and there is an entire apparatus in the cells to handle those cases and clean them up.
On a sidenote, what is this new style of writing using small sentences where each sentence is supposed to be a punchline?
"And most of those sequences? They don't fold into anything useful. They're junk. They aggregate into clumps. They get degraded by cellular quality control. Only a TINY fraction of possible sequences fold into stable, functional proteins."
If nature did so well for billions of years, why are we taking over it's job now? Did it ask for your help?
Anytime some talks about large numbers - some galaxy is billions of kilometers away, there are trillions of atoms in universe, trillions of possible combinations for a problem etc - it appears to me that you talking about some problem that doesn't fall into your job description.
9 comments
[ 3.2 ms ] story [ 30.0 ms ] threadAnd I do love the optimism.
But then you must admit this reads like a B-movie intro:
I'm quite impressed by the amino acid overview graphic. I'm sure all images are AI-generated, and this one is something I didn't expect AI to be able to do yet. There are mistakes in there (e.g. Threenine instead of Threonine, charged amino groups for some amino acids), but it doesn't look immediately wrong. Though I haven't needed to know the chemical formular for all the amino acids in a long time, so there are probably more errors in there I didn't immediately notice. The angles and lengths of the bonds are not entirely consistent, but that also happens without AI sometimes if someone doesn't know the drawing tools well. The labels are probably the clearest indicator, because they are partly wrong and they are not consistent as they also include the non-side-chain parts sometimes, which doesn't make sense.
The biology part of the text looks somehwat reasonable overall, I didn't notice any completely outrageous statements at a quick glance. Though I don't like the "folding is reproducible" statement as that is a huge oversimplification. Proteins do misfold, and there is an entire apparatus in the cells to handle those cases and clean them up.
How many H100s do you need to simulate one human cell? Probably more than the universe can power.
On a sidenote, what is this new style of writing using small sentences where each sentence is supposed to be a punchline?
"And most of those sequences? They don't fold into anything useful. They're junk. They aggregate into clumps. They get degraded by cellular quality control. Only a TINY fraction of possible sequences fold into stable, functional proteins."
Anytime some talks about large numbers - some galaxy is billions of kilometers away, there are trillions of atoms in universe, trillions of possible combinations for a problem etc - it appears to me that you talking about some problem that doesn't fall into your job description.