"Influenza vaccination is associated with significantly lower odds of myocardial infarction (MI), according to a large meta-analysis published late last week in BMC Public Health."
I can't find a specific source right now, but I remember reading that RFK's war on mRNA vaccines only applies the ones used for flu/Covid. They haven't gone after cancer vaccines.
Future me would have a really high quality EV with an amazing charging network, clean air and water, a habitable planet for my grand children, no domestic political extrajudicial paramilitary surveilling everyone with megawarehouse detention cities everywhere, outright ideological warfare against urban areas, etc.
We had a choice between Star Trek future world and Blade Runner+MadMax+Idiocracy, and we predictably chose the one we deserve because memes and a podcast.
Biontech, the one that had the first mrna vaccine, has a bunch of phase 3 trials this year, and they're all about curing cancer - it's literally how they're using all of the covid vaccine revenue, as funding for that endeavor.[1]
Except this is not how medical regulation has worked in the US. This particularly is a new and stricter standard required for this particular vaccine. Even the new Trump policies for COVID vaccines now specifically requires a placebo -- comparison against standard-of-care would not be accepted.
> In the US for adults 65+ (a key high-risk group in the trial), the ACIP preferentially recommends higher-antigen or adjuvanted options like Sanofi, Seqirus adjuvanted, recombinant high-antigen Flublok, etc as the "best-available standard of care",
Did this recommendation come before or after RFK Jr. fired all members of the ACIP and replaced them with his hand-picked choices? I suspect you already know the answer.
> * The "standard flu shot" Moderna used is likely not one of the above, or they would have said so
They didn't have to. The FDA told them they could continue to use standard flu shot if they wanted to as long as some statements were included in consent forms.
> The idea here is to see if the new shot is meaningfully better than the best existing/approved option for the target demographic, not to see if it's better than a standard shot you give a healthy 20-year-old.
No that's not the idea at all.
> All-in-all feels like a nothingburger.
No, it's not a nothingburger. It's a systematic assault on science and medicine.
> In a release Tuesday, Moderna said the FDA did not identify any safety or efficacy concerns with the vaccine. Instead, it said the FDA took issue with the “comparator” in its clinical trial — the vaccine the company used as a benchmark to evaluate its own shot.
> The FDA said the use of the standard flu shot as a comparator “does not reflect the best-available standard of care.”
Are they implying that a placebo should be the comparator?
What's crazy here is that FDA finally has a great head who actually tries to speed things up using Bayesian data modeling and understands drugs quite well (Marty
Makary) and does everything to make drug approval process cheaper and more efficient without compromising safety.
Unfortunately it seems like this decision was overwritten by his boss for political a win.
17 comments
[ 3.3 ms ] story [ 50.1 ms ] thread"Influenza vaccination is associated with significantly lower odds of myocardial infarction (MI), according to a large meta-analysis published late last week in BMC Public Health."
https://www.cidrap.umn.edu/influenza-vaccines/new-analysis-l...
This press release seems to confirm this: https://biontechse.gcs-web.com/news-releases/news-release-de...
We had a choice between Star Trek future world and Blade Runner+MadMax+Idiocracy, and we predictably chose the one we deserve because memes and a podcast.
1 https://european-biotechnology.com/latest-news/2026-a-year-o...
So?
> In the US for adults 65+ (a key high-risk group in the trial), the ACIP preferentially recommends higher-antigen or adjuvanted options like Sanofi, Seqirus adjuvanted, recombinant high-antigen Flublok, etc as the "best-available standard of care",
Did this recommendation come before or after RFK Jr. fired all members of the ACIP and replaced them with his hand-picked choices? I suspect you already know the answer.
> * The "standard flu shot" Moderna used is likely not one of the above, or they would have said so
They didn't have to. The FDA told them they could continue to use standard flu shot if they wanted to as long as some statements were included in consent forms.
> The idea here is to see if the new shot is meaningfully better than the best existing/approved option for the target demographic, not to see if it's better than a standard shot you give a healthy 20-year-old.
No that's not the idea at all.
> All-in-all feels like a nothingburger.
No, it's not a nothingburger. It's a systematic assault on science and medicine.
> The FDA said the use of the standard flu shot as a comparator “does not reflect the best-available standard of care.”
Are they implying that a placebo should be the comparator?
we need to cut the required lead time down to weeks, rather than months.
we also need to stand up a surveilance network again.
Unfortunately it seems like this decision was overwritten by his boss for political a win.