The measured concentrations are on the order of 1-20 ng/mL in blood. Cmax in humans when taking those drugs are about 100-1000x higher.
I wouldn't put too much weight on the finding that those with detections had different urea/lactate etc. There might be something underlying explaining both drug and physiology, like age.
Could still be bad to have chronic exposure at such low levels - also fish physiology is different.
Not surprising. A lot of these substances get metabolized, or just diluted by water and filtered out without being like, magically deconstructed and turned into all CO2 and H2O and N2. So a lot of wacky chemical compounds humans tend to consume tend to get detected wherever humans gather and discharge bodily fluids that eventually reach the ocean. This does not immediately indicate that e.g. evil corporations are dumping toxic wastes, forever plastics pieces are leaching out scary additives, etc.
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I wouldn't put too much weight on the finding that those with detections had different urea/lactate etc. There might be something underlying explaining both drug and physiology, like age.
Could still be bad to have chronic exposure at such low levels - also fish physiology is different.