Is it me or they very carefully do not report performance on GPT-5.4 Pro, only the default GPT-5.4? They also very carefully left Anthropic models out of their comparison.
I went back to the BixBench benchmark which they mentioned. I couldn't find official results for Anthropic models, but I found a project taking Opus 4.6 from 65.3% to 92.0% (which would be above GPT-Rosalind) with nearly 200 carefully crafted skills [1]. There also appears to be competitive competitor models with scores on par with this tuned GPT.
Bix Bench seems like a really interesting/useful idea but most of the value for a layperson (like me) is comparing the results of different models on the benchmark. From what I can find there is no centralised & updated model results set. Shame.
The voiceover in the promo video on this page seems to be AI generated, with some weird artifacts. Right at the beginning it sounds like it says "cormbiying structure daya retrieval and lirrachure search".
I work for a life sciences company. It will be a long time before anyone trusts a generative model to do the actual science when mathematically provable models are as good as they are today. There is room for AI in the field, but it's not in the science directly.
If you have something like this, how about you demonstrate a way to really help, and demonstrate (as opposed to claim) what this can do? Make a cheap vaccine against the new resistant forms of TBC, or if you truly want to impress, against HIV. DON'T get it approved at all, just publish how it would work, maybe with a simulation (so it can't be patented). This shouldn't even be so hard, it's just really hard to make money on either of those vaccines, as right 1st world countries have little need for them (HIV, perhaps, but vaccines don't make much money. A TBC vaccine, definitely doesn't make money), so you're not "getting in the way of business" doing that.
Why? AI's reputation would be greatly improved by saving a few 10s of millions of lives (per year, I might add). And either of those advances would do just that.
Oh, and another reason. Do either of these things and you'll have very rich businesses screaming to become your customer coming out of every hole. Guaranteed.
While this model set (GPT-Rosalind) is limited to certain organizations, the announcement also included the release of a Life Sciences Plugin, which is more broadly available on Codex [1].
13 comments
[ 3.4 ms ] story [ 35.2 ms ] threadI went back to the BixBench benchmark which they mentioned. I couldn't find official results for Anthropic models, but I found a project taking Opus 4.6 from 65.3% to 92.0% (which would be above GPT-Rosalind) with nearly 200 carefully crafted skills [1]. There also appears to be competitive competitor models with scores on par with this tuned GPT.
[1] https://github.com/jaechang-hits/SciAgent-Skills
Sam Altman, August 2025
https://www.bbc.com/news/articles/cy5prvgw0r1o
Why? AI's reputation would be greatly improved by saving a few 10s of millions of lives (per year, I might add). And either of those advances would do just that.
Oh, and another reason. Do either of these things and you'll have very rich businesses screaming to become your customer coming out of every hole. Guaranteed.
[1] https://github.com/openai/plugins/tree/main/plugins/life-sci...