What Ozempic does to the gut-brain axis (psychologytoday.com)

I'd take them even if they didn't make me lose weight - and I'm the type of person that doesn't like takeing Tylenol unless absolutely necessary.

The best way I can describe it: my body and mind are no longer is in starvation mode. I plan, do, act and sleep well.

Mice are not people, but interesting link

Could be related to endorphins and BDNF, similar to the effect from fasting.

I got severely downvoted in the past for badmouthing GLP1s here. Then I did my research, got on them and I take it all back. These things are on par with statins in terms of potential societal impacts.

As a habitual habit developer, Im keeping my hopes up that in 5 or 10 years, this is something that can help me and many others.

I've read experiences from people on illicit substances that claimed they helped them quit.

It would be beat if this carried over to things like caffeine/nicotine/thc/etc.

Metabolic theories of mental illnesses and cancer are seriously understudied.

I'm curious if this post will also have the same phenomena I've seen before of people springing out of the woodwork to post moralizing comments about people shouldn't rely on drugs, about how actually GLP-1s are bad because they don't fix problems indefinitely with a single dose, about how people should fix their problems by just having more willpower, talking about 'but what about the unknown side effects?' of drugs that have been in use for twenty years already, etc.

so, the whole mouse thing is a scam, and now they are openly testing on us, first, and publishing in psychology today to see if we notice.fiendish.

My insurance stopped covering, now I'm looking at $450 for Zepbound / month. Just the weight coming back is making me more depressed...

Hasn't done jack shit for my depression.

Also worth mentioning GLP1's are known to cause anhedonia. So there's that...

What about the reports of bone density loss? Any downsides to this?

What’s the downside to this magical drug. There has to be a downside…

The more I hear about GLP-1 drugs, the more I think there is something to the joking suggestion of putting it in the water supply.

The "gut-brain axis" is mostly bullshit invented to cope with the fact that doctors have sent patients to shrinks for decades with real sicknesses. Everybody knows you feel bad when your digestive is out of balance. It's the same english word for "I'm sick" and "I feel sick" since forever. No magical newly found "gut-brain axis" needed.

Eating junk food, especially sweetened food is a drug. You can do a withdrawal and get the reduction of food noise reported with semaglutide without getting dependent on another drug with so far unknown long-term effects.

In mice

Edit: the title should have such a tag

Great drugs. Have dropped 10+kg couple of times and tried a few more with low carb. Dropped 20+kg with Ozempic and it boosted me to exercise. Its wonderful that even a string of bad nights don't push me to overeat: even if I eat more during the day it tapers of in the evening whereas before ut would just continue.

From my real world experience of a few dozen patients, there is definitely a mood boost but only to those who lost weight. The effect may be due to the weight loss confidence and/or other mechanism. The cause seems difficulty to find.

My advice: in monopolar depression with increased weight especially due to binge eating take the SSRI Fluoxetine 20mg 1 up to 2 daily. It will make wonders.

Wish I had that microbe. Ozempic made me suicidal. Still here though. Zepbound doesn't that that effect. Maybe the smaller dosage of the GLP-1.

It just says 403 Forbidden?

There's no free lunch so what's the downside? I don't believe in ghosts, and I DON'T believe in miracle cures.