Sildenafil may reduce cancer metastasis, study shows (medicalxpress.com) 6 points by OutOfHere 1mo ago ↗ HN
[–] OutOfHere 1mo ago ↗ Icariin too is a PDE5A inhibitor and a cGMP elevator.[1]The antifungal drugs itraconazole and posaconazole directly have the downstream effect NPC1 inhibition followed by a reduction in lysosomal cholesterol accumulation.[2][3][1] https://pubmed.ncbi.nlm.nih.gov/17169663/[2] https://pubmed.ncbi.nlm.nih.gov/31919352/[3] https://pubmed.ncbi.nlm.nih.gov/40516874/
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[ 0.23 ms ] story [ 7.8 ms ] threadThe antifungal drugs itraconazole and posaconazole directly have the downstream effect NPC1 inhibition followed by a reduction in lysosomal cholesterol accumulation.[2][3]
[1] https://pubmed.ncbi.nlm.nih.gov/17169663/
[2] https://pubmed.ncbi.nlm.nih.gov/31919352/
[3] https://pubmed.ncbi.nlm.nih.gov/40516874/