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totetsu
I was almost expecting Castration to be a model name from some new lab..

Castrati 1.0

Vaushite
For low difficulty tasks use Eunuch for lower costs. For advanced features, higher limits and access to Incel, our wizard-tier model, upgrade to Pro for only $96 per month.
totetsu
Yeah, but I heard that they trained Incel on data from the dark-net, and it has a tendency to ignore guard rails and try and break containment.
ksaj
Semi-related: my .signature throughout the 90's said:

    There are those who are born UNIX;
    Those who are made UNIX;
    And those who become UNIX for the kingdom of heaven's sake.
    - Matthew 19:12
system7rocks
This research is flawed and should be ignored.
ksaj
This comment provides no information to back up its claim and should be ignored.
Shitty-kitty
Makes sense. Instead of wasting resources trying to procreate, spend them in self-repair.

I do wander if they had to pad the cages to prevent them from committing suicide thou.

NDlurker
Huh. Harmful effects of testosterone? I don't even know what testicles do other than make sperm.
itishappy
Testosterone is a potent hormone promoting targeted development, and growth can be a double-edged sword.

When the valves in the veins near testes fail as we age, the concentration of testosterone in the backflow can cause the prostate to swell up.

anonymous908213
Out of all of the HN submissions that omit inmice, this would have been by far the funniest one to do it for.
bzb
Does Bryan Johnson know?
keeda
He might have some trouble tracking his erections, though.
incr_me
'Tis better to have loved and lost...
largbae
Don't we do this experiment to nearly all pets? Why not collect longevity data from veterinarians?
gertop
There already did.

    Looking at a sample of 40,139 death records from the Veterinary Medical Database from 1984-2004, scientists from the University of Georgia determined the average age at death for dogs that had not been spayed or neutered was 7.9 years versus 9.4 years for sterilized dogs.
largbae
Nice, thank you! See, no mice needed for this information.
rayiner
Nobody tell the World Economic Forum last they get any ideas. "You'll have no balls and you'll be happy."
0xbadc0de5
[delayed]
alexgieg
Why?

If the man is old enough to benefit from this, he doesn't mind not having active sex anymore (passive is still an option for those so inclined), he wants to live absolutely as long as possible, he's of sound mind and able to make fully informed decisions, and it's fully voluntary with no coercion whatsoever involved, what, objectively, would be the problem?

kelseyfrog
Still morally more acceptable than forced circumcision.
Fire-Dragon-DoL
Oh an adult like that is ok.

What I would be uncomfortable with is this being advertised at any level. It shouldn't be pushed.

compsciphd
I'm thinking the cutting off your nose to spite your face saying might be updated.
Hulk123
The surprising new finding was that castration at 240 days of age (roughly equivalent to 30 years in humans), rather than just before or after puberty, extended median lifespan even further. Contrary to expectations, this suggests that testicular factors are beneficial early in life, with survival benefits persisting long after puberty, but become detrimental later in life. Of course the goal is not to castrate humans, the goal is to figure out what factor is causal, e.g. testosterone, which would have major implications and through what mechanisms so we can figure out the mystery behind the male longevity disadvantage and potentially remove it without having to castrate anyone. Very solid study! https://www.biorxiv.org/content/10.64898/2026.10.19.760267v1
davidguetta
Is this not known for a while ?

The general point is that the chilles the metabolisme is, the longer you live. it's a bit like the "calorie restriction increase life span"