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I don't really think it's "dreaming big". Compare that to Elon Musk.
Do you mean that as in it isn't worth doing? By that logic hardly anyone would be doing anything.
It's interesting to see at least 3 companies focused on fundraising (or crowdfunding) in this batch. Watsi (https://watsi.org/ + http://techcrunch.com/2012/08/30/watsi/) and Microryza (https://www.microryza.com/ + http://techcrunch.com/2013/02/25/microryza-yc/) are also focusing on funding medical treatments and scientific research.

Also, getting public figures like Stephen Fry and Jamie Oliver is really great thinking, they are the perfect type of celebrity to help start something like this.

I hate this. On one hand you get something good: more money to charity, but on the other hand you get someone else taking all the credit for it.
"Tap fans" sounds close to "milk cows" to me.