Ask HN: What would you use an epic supercomputer for?

If you had a computer in your possession that was 100, or even 1000, times more powerful than supercomputers available today, what would you use it for?

What kind of commercial applications could processing power of that kind provide do you think? Out of the box ideas are more than welcome :).

Hypothetical question... of course :)

I'm thinking such a system could have some interesting implications for cryptoanalysis, for one.